Lee Kkot Sil, Kim Tae Hyong, Kim Eu Suk, Lim Hyeong-Seok, Yeom Joon-Sup, Jun Gyo, Park Jae-Won
Department of Internal Medicine, Kwandong University College of Medicine, Seoul, Republic of Korea.
Am J Trop Med Hyg. 2009 Feb;80(2):215-7.
The number of Plasmodium vivax malaria patients in the Republic of Korea and North Korea since the re-emergence of malaria in 1993 is estimated to be approximately one million. To cope with this situation, the Army of the Republic of Korea has performed chemoprophylaxis with hydroxychloroquine and primaquine since 1997. The cumulative number of soldiers in the Army of the Republic of Korea given chemoprophylaxis exceeded 1.4 million by 2007. Extensive chemoprophylaxis contributed to preventing a rapid increase of malaria patients in the Army of the Republic of Korea, but increased the possibility of the occurrence of chloroquine (CQ)-resistant P. vivax strains. In this study, treatment responses of P. vivax malaria patients in the Republic of Korea monitored during 2003-2007, and CQ resistance was confirmed in 2 of 484 enrolled patients. Our results are the first report of CQ-resistant P. vivax in a temperate region of Asia. Continuous surveillance is warranted to monitor the change in CQ resistance frequency of P. vivax in the Republic of Korea.
自1993年疟疾再次出现以来，据估计，大韩民国和朝鲜间日疟原虫疟疾患者的数量约为100万。为应对这种情况，大韩民国陆军自1997年起采用羟氯喹和伯氨喹进行化学预防。截至2007年，接受化学预防的大韩民国陆军士兵累计人数超过140万。广泛的化学预防有助于防止大韩民国陆军疟疾患者数量的快速增加，但增加了出现氯喹（CQ）耐药间日疟原虫菌株的可能性。在本研究中，对2003 - 2007年期间监测的大韩民国间日疟原虫疟疾患者的治疗反应进行了观察，在484名登记患者中有2例证实存在CQ耐药。我们的结果是亚洲温带地区间日疟原虫CQ耐药的首次报告。有必要持续监测，以监测大韩民国间日疟原虫CQ耐药频率的变化。
