["“干”浸泡期间发生的生态失调调查及纠正方法"]
[Investigation of dysbiosis developing during "dry" immersion and methods of correction].
作者信息
Il'in V K, Kriukov A I, Volozhin A I, Istranov L P, Istranova E V, Kiriukhina N V, Starkova L V, Morozova Iu A, Usanova N A
出版信息
Aviakosm Ekolog Med. 2008 Sep-Oct;42(5):70-4.
Dysbiotic shifts in intestinal and integumentary microflora were studied in 10 test-subjectes during 7-day "dry" immersion. Essentially every test-subject reduced significantly fecal lactoflora and developed dysbiotic shifts in the microbial landscape of various types of integument. Pharyngeal microflora was analyzed in 22 normal volunteers for 7-day "dry" immersion. Two probiotic preparations were administered to prevent pharyngeal dysbiosis: peroral dry lactobacterin and topical collagen-immobilized lactobacterin. The peroral probiotic stimulated growth of pharyngeal opportunistic pathogens preventing translocations of the intestinal microflora. The topical probiotic, on the opposite, reduced the content of opportunistic pathogens in the throat; however, it provoked gastrointestinal dysbiosis. It appears that the most effective prophylaxis of pharyngeal dysbiosis can be reached by prescription of both topical and peroral probiotics.
在10名受试者进行为期7天的“干”浸期间，研究了肠道和皮肤微生物群的生态失调变化。基本上每个受试者的粪便乳杆菌群都显著减少，并且在各种类型皮肤的微生物环境中出现了生态失调变化。对22名正常志愿者进行了为期7天的“干”浸，并分析了其咽部微生物群。给予两种益生菌制剂以预防咽部生态失调：口服干乳酸菌素和局部应用胶原蛋白固定化乳酸菌素。口服益生菌刺激了咽部机会致病菌的生长，从而防止肠道微生物群的移位。相反，局部应用的益生菌降低了咽喉部机会致病菌的含量；然而，它引发了胃肠道生态失调。看来，通过局部和口服益生菌联合用药可以实现对咽部生态失调的最有效预防。
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