Rothamel Daniel, Schwarz Frank, Herten Monika, Berndsen Kathrin, Steigmann Marius, Neugebauer Jörg, Becker Jürgen
Poliklinik für Zahnärztliche Chirurgie, Westdeutsche Kieferklinik, Heinrich-Heine-Universität Düsseldorf, Deutschland.
Schweiz Monatsschr Zahnmed. 2008;118(12):1162-9.
The aim of the present study was to histologically evaluate vertical ridge augmentation of the mandible using partially deproteinized cortico-spongious xenogenous blocks (XB) in dogs. Standardized acute-typed vertical lower jaw defects were surgically created in edentulous ridges of six foxhounds. Two similar bone blocks of 6 mm height were randomly inserted on each mandibular side and fixed with both a titanium implant and an osteosynthetic screw. Three groups were tested: i) XB (CS-Block bovin, Tutogen Medical) alone, ii) XB covered with a native xenogenous collagen membrane (XB+M) (Tutodent Membran, Tutogen Medical), and iii) autogenous blocks (AB), harvested during defect preparation from the ipsi- and contralateral side. After three months of submerged healing, the miniscrews were removed and replaced by secondary dental implants. In general, histological analysis revealed that augmentation of XB, used alone or in combination with a collagen membrane, did not lead to significant supracrestal bone apposition, resulting in means of 14 +/- 9% for XB and 25 +/- 9% for XB+M of basal ossification of the blocks. AB revealed significantly higher ossification rates of 46 +/- 16%. BIC rates were significantly higher for AB (70 +/- 15%) than for XB (26 +/- 15%) and XB+M (32 +/- 12%) (P < 0.05, Mann Whitney U-Test, respectively). Within the limits of the present study it was concluded that XB alone or in combination with a collagen membrane doesn't seem to be useful for vertical ridge augmentation procedures of the mandible.
本研究的目的是通过组织学方法评估在犬下颌骨中使用部分脱蛋白的皮质松质异体骨块（XB）进行垂直牙槽嵴增高术的效果。在六只猎狐犬的无牙牙槽嵴上通过手术制造标准化的急性型垂直下颌骨缺损。在每侧下颌骨随机植入两个高度为6mm的相似骨块，并用钛种植体和骨固定螺钉进行固定。测试了三组：i）单独使用XB（CS-Block bovin，Tutogen Medical公司），ii）XB覆盖天然异体胶原膜（XB+M）（Tutodent Membran，Tutogen Medical公司），iii）自体骨块（AB），在缺损制备过程中从同侧和对侧获取。经过三个月的潜行愈合后，取出微型螺钉，替换为二期牙种植体。总体而言，组织学分析显示，单独使用或与胶原膜联合使用的XB均未导致明显的牙槽嵴顶骨附着增加，骨块基底骨化的平均值在XB组为14±9%，在XB+M组为25±9%。AB组显示出明显更高的骨化率，为46±16%。AB组的骨结合率（70±15%）显著高于XB组（26±15%）和XB+M组（32±12%）（分别为P<0.05，Mann Whitney U检验）。在本研究的范围内得出结论，单独使用XB或与胶原膜联合使用似乎对下颌骨垂直牙槽嵴增高术无效。
