Department of Oral-, Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstr. 5, Düsseldorf, Germany.
Department of Oral-, Maxillofacial and Facial Plastic Surgery, Evangelisches Krankenhaus Bethesda, Ludwig-Weber-Straße 15, 41061, Mönchengladbach, Germany.
Clin Oral Investig. 2021 Jun;25(6):3729-3737. doi: 10.1007/s00784-020-03700-y. Epub 2021 Jan 12.
Biphasic calcium phosphate (BCP) is a bioceramic material successfully used in alloplastic bone augmentation. Despite many advantages, a disadvantage of BCP seems to be a difficult application and position instability. The aim of this study was to determine how different carrier materials influence BCP-induced quantitative and qualitative bone regeneration.
A total of 70 critical size defects were set in the frontal bone of 14 domestic pigs (5 each) and filled randomly with either BCP alone (BCP), BCP in combination with nano-hydroxyapatite (BCP + NHA), BCP embedded in native porcine type I/III collagen blocks (BCP + C), autologous bone (AB), or were left empty (ED). Specimens were harvested after 4 and 8 weeks and were evaluated histologically as well as histomorphometrically.
Significantly lowest rate of new bone formation was found in ED (p = < 0.001) and BCP + NHA groups (p = 0.05). After 8 weeks, the highest percentage of new bone formation was observed in the BCP + C group. Fibrous matrix was detected highest in BCP alone. The lowest residual bone substitute material was found in BCP + C after 8 weeks.
BCP-induced bone regeneration is indeed affected by different carrier types. Surface morphology and bioactive characteristics influence osseointegration and new bone formation in vivo. The combination of type I/III collagen seems most suitable for qualitative and quantitative bone regeneration.
Stabilization of granular bone substitutes using type I/III collagen might be an alternative to granulates alone, indicating excellent volume stability, satisfactory plasticity, and easy application.
双相磷酸钙（BCP）是一种成功应用于同种异体骨增强的生物陶瓷材料。尽管有许多优点，但 BCP 的一个缺点似乎是应用困难和位置不稳定。本研究旨在确定不同载体材料如何影响 BCP 诱导的定量和定性骨再生。
在 14 头国产猪的额骨中总共设置了 70 个临界尺寸缺陷（每个 5 个），并随机用 BCP 单独（BCP）、BCP 与纳米羟基磷灰石（BCP + NHA）组合、BCP 嵌入天然猪 I/III 型胶原块（BCP + C）、自体骨（AB）或空白（ED）填充。标本在 4 周和 8 周后取出，进行组织学和组织形态计量学评估。
ED（p < 0.001）和 BCP + NHA 组（p = 0.05）的新骨形成率最低。8 周后，BCP + C 组的新骨形成率最高。单独的 BCP 中检测到最高的纤维基质。8 周后，BCP + C 组中残留的骨替代材料最少。
BCP 诱导的骨再生确实受到不同载体类型的影响。表面形态和生物活性特征影响体内的骨整合和新骨形成。I/III 型胶原的组合似乎最适合定性和定量的骨再生。
使用 I/III 型胶原稳定颗粒状骨替代物可能是替代单独颗粒的一种选择，表明具有极好的体积稳定性、满意的可塑性能和易于应用。
