Sakano Chieko, Morita Yukio, Shiono Masataka, Yokota Yoko, Mokudai Toshie, Sato-Motoi Yurie, Noda Akiyo, Nobusawa Toshio, Sakaniwa Hiroyuki, Nagai Akira, Kabeya Hidenori, Maruyama Soichi, Yamamoto Shigeki, Sato Hiroshi, Kimura Hirokazu
Gunma Prefectural Meat Inspection Laboratory, 305-7 Higoshi, Tamamura, Sawa, Gunma, Japan.
J Vet Med Sci. 2009 Jan;71(1):21-5. doi: 10.1292/jvms.71.21.
The prevalence of hepatitis E virus (HEV) infection in wild boars and pigs in Gunma Prefecture, Japan, was serologically and genetically examined. The positive detection rates of anti-HEV IgG and HEV RNA in the wild boars were 4.5% (4/89) and 1.1% (1/89), whereas those in the pigs were 74.6% (126/169) and 1.8% (3/169), respectively. The positive rates of anti-HEV IgG and HEV RNA on the 17 pig farms in the present study ranged from 20% to 100%, respectively. One male wild boar approximately 5 years of age was positive for HEV RNA but was negative for anti-HEV IgG. Three pigs from 2 farms were positive for HEV RNA; 2 of these pigs were negative for HEV IgG, and the other was positive. A phylogenetic analysis revealed that all of the HEV ORF1 genes detected in the present study belonged to genotype III. In Gunma Prefecture, HEV is highly prevalent and widespread, and uncooked wild boar and pig meat may have the potential to transmit HEV to humans.
对日本群马县野猪和家猪中戊型肝炎病毒（HEV）感染的流行情况进行了血清学和基因检测。野猪中抗HEV IgG和HEV RNA的阳性检出率分别为4.5%（4/89）和1.1%（1/89），而家猪中的阳性检出率分别为74.6%（126/169）和1.8%（3/169）。本研究中17个养猪场的抗HEV IgG和HEV RNA阳性率分别为20%至100%。一头约5岁的雄性野猪HEV RNA呈阳性，但抗HEV IgG呈阴性。来自2个猪场的3头猪HEV RNA呈阳性；其中2头猪抗HEV IgG呈阴性，另一头呈阳性。系统发育分析表明，本研究中检测到的所有HEV ORF1基因均属于基因型III。在群马县，HEV高度流行且广泛传播，未经烹饪的野猪和猪肉可能有将HEV传播给人类的潜在风险。
