脂肪组织中的三酰甘油代谢。
Triacylglycerol metabolism in adipose tissue.
作者信息
Ahmadian Maryam, Duncan Robin E, Jaworski Kathy, Sarkadi-Nagy Eszter, Sul Hei Sook
机构信息
University of California, Department of Nutritional Sciences & Toxicology, Berkeley, CA 94720, USA, Tel.: +1 510 642 3978; ;
出版信息
Future Lipidol. 2007 Apr;2(2):229-237. doi: 10.2217/17460875.2.2.229.
Abstract
Triacylglycerol (TAG) in adipose tissue serves as the major energy storage form in higher eukaryotes. Obesity, resulting from excess white adipose tissue, has increased dramatically in recent years resulting in a serious public health problem. Understanding of adipocyte-specific TAG synthesis and hydrolysis is critical to the development of strategies to treat and prevent obesity and its closely associated diseases, for example, Type 2 diabetes, hypertension and atherosclerosis. In this review, we present an overview of the major enzymes in TAG synthesis and lipolysis, including the recent discovery of a novel adipocyte TAG hydrolase.
摘要
脂肪组织中的三酰甘油（TAG）是高等真核生物中主要的能量储存形式。近年来，由白色脂肪组织过多导致的肥胖症急剧增加，引发了严重的公共卫生问题。了解脂肪细胞特异性的TAG合成和水解对于制定治疗和预防肥胖症及其密切相关疾病（如2型糖尿病、高血压和动脉粥样硬化）的策略至关重要。在这篇综述中，我们概述了TAG合成和脂解过程中的主要酶，包括最近发现的一种新型脂肪细胞TAG水解酶。
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