Ishii T, Nakamura Y
Acta Neuropathol. 1981;55(1):59-62. doi: 10.1007/BF00691532.
The distribution and ultrastructure of Alzheimer's neurofibrillary tangles (ANT) in the brain stem, hypothalamus, and Ammon's horn were studied in four patients with postencephalitic parkinsonism of Economo type (PEPE). The distribution of ANT was as previously reported; the pattern of distribution resembled to that of amine-containing nerve cells. Ultrastructurally, ANT revealed twisted tubules (TT), but straight tubules (ST) of 150 A width were also found in the locus ceruleus of three cases; sometimes, TT and ST were mixed in a single neuron. Whether the coexistence of TT and ST in the locus ceruleus is a characteristic ultrastructural feature of ANT in PEPE or a regional peculiarity could not be determined. Ultrastructurally, ANT in PEPE were identical to those found in the brains of patients with Alzheimer's disease or senile dementia.
对4例埃科诺莫型脑炎后帕金森综合征（PEPE）患者的脑干、下丘脑和海马进行了阿尔茨海默病神经原纤维缠结（ANT）的分布及超微结构研究。ANT的分布与先前报道一致；其分布模式类似于含胺神经细胞的分布模式。超微结构上，ANT显示为扭曲小管（TT），但在3例患者的蓝斑中还发现了宽度为150埃的直小管（ST）；有时，TT和ST在单个神经元中混合存在。蓝斑中TT和ST的共存是PEPE中ANT的特征性超微结构特征还是区域特殊性尚无法确定。超微结构上，PEPE中的ANT与阿尔茨海默病或老年痴呆患者大脑中发现的ANT相同。
