Gu Danan, Dupre Matthew E, Sautter Jessica, Zhu Haiyan, Liu Yuzhi, Yi Zeng
Nohad A. Toulan School of Urban Studies and Planning, Portland State University, 506 SW Mill St. 570M, Portland, OR 97207, USA.
J Gerontol B Psychol Sci Soc Sci. 2009 Mar;64(2):279-89. doi: 10.1093/geronb/gbn009. Epub 2009 Feb 4.
This study investigates the factors associated with frailty and the association of frailty with mortality in a national sample of adults aged 65-109 in China.
Using the 2002 wave of the Chinese Longitudinal Healthy Longevity Survey, we construct a frailty index (FI) based on 39 measures available in the data set. We use ordinal logistic regressions to examine the factors associated with the FI and use Weibull hazard regression to examine the association between frailty and 3-year mortality from 2002 to 2005.
Age, sex, ethnicity, urban-rural residence, economic condition, religious involvement, and daily exercise are significantly associated with levels of frailty. Hazard analyses further reveal that the FI is a robust predictor of mortality at advanced ages and that the relationship between frailty and mortality is independent of various covariates. Discussion The measurement and analysis of frailty have broad implications for public health initiatives designed to target individuals with the diminished capacity to effectively compensate for external stressors and to prevent further declines associated with aging and mortality. A key to healthy longevity is the prevention, postponement, and potential recovery from physical and cognitive deficits at advanced ages through enhanced medical interventions and treatments.
本研究在中国65至109岁成年人的全国样本中，调查与衰弱相关的因素以及衰弱与死亡率之间的关联。
利用2002年中国老年健康影响因素跟踪调查的数据，我们基于数据集中可得的39项指标构建了一个衰弱指数（FI）。我们使用有序逻辑回归来检验与衰弱指数相关的因素，并使用威布尔风险回归来检验2002年至2005年期间衰弱与3年死亡率之间的关联。
年龄、性别、民族、城乡居住地、经济状况、宗教参与度和日常锻炼与衰弱程度显著相关。风险分析进一步表明，衰弱指数是高龄死亡率的一个可靠预测指标，并且衰弱与死亡率之间的关系独立于各种协变量。讨论 衰弱的测量和分析对旨在针对那些有效应对外部压力源能力下降的个体以及预防与衰老和死亡相关的进一步衰退的公共卫生举措具有广泛影响。健康长寿的一个关键是通过加强医疗干预和治疗，预防、推迟高龄时的身体和认知缺陷，并实现潜在的恢复。
