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Antimalarial sesquiterpenes from tubers of Cyperus rotundus: structure of 10,12-peroxycalamenene, a sesquiterpene endoperoxide.

作者信息

Thebtaranonth C, Thebtaranonth Y, Wanauppathamkul S, Yuthavong Y

机构信息

National Science and Technology Development Agency, Bangkok, Thailand.

出版信息

Phytochemistry. 1995 Sep;40(1):125-8. doi: 10.1016/0031-9422(95)00260-e.

DOI:10.1016/0031-9422(95)00260-e
PMID:7546546
Abstract

Activity-guided investigation of Cyperus rotundus tubers led to the isolation of patchoulenone, caryophyllene alpha-oxide, 10,12-peroxycalamenene and 4,7-dimethyl-1-tetralone. The antimalarial activities of these compounds are in the range of EC50 10(-4)-10(-6) M, with the novel endoperoxide sesquiterpene, 10,12-peroxycalamenene, exhibiting the strongest effect at EC50 2.33 x 10(-6) M.

摘要

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