Sibila M, Martínez-Guinó L, Huerta E, Mora M, Grau-Roma L, Kekarainen T, Segalés J
Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Vet Microbiol. 2009 Jun 12;137(3-4):354-8. doi: 10.1016/j.vetmic.2009.01.008. Epub 2009 Jan 7.
Torque teno virus (TTV) is a single-stranded DNA virus that has been detected in serum of primate and non-primate species including swine. Little information on swine TTV infection and transmission dynamics is nowadays available. The goal of this study was to gain insight into the potential role of the sow in transmitting TTV to piglets and the infection dynamics of both swine TTV genogroups (TTV1 and TTV2) during the lactation period. Serum samples from 44 sows at 1-week post-farrowing and 215 piglets at 1 and 3 weeks of age were tested using TTV1 and TTV2 PCR methods. Sow parity distribution and the number of delivered piglets (liveborn, stillborn and mummified) per each studied sow were recorded. TTV1 was detected in higher percentages than TTV2 in both sows (75% vs. 43%, respectively) and piglets at 1 (17% vs. 7%, respectively) and 3 (32% vs. 12%, respectively) weeks of age. TTV1 and TTV2 co-infections were observed in higher percentages in sows (34%) than in piglets (2% and 4% at 1 and 3 weeks of age, respectively). Detection of swine TTV genogroups in sows was not associated with their detection in piglets. Moreover, there were piglets infected at 1 week of age with a swine TTV genogroup different from the one detected in their dam. The number of sows delivering stillborns and the mean number of stillborns per sow tended to be higher in the TTV2 infected sows; this value was significantly higher when co-infected sows (TTV1 and TTV2) were compared with non-co-infected ones. Old parity sows had a higher percentage of TTV1 infected 1-week-old piglets. Results of the present study showed that the TTV infection occurs early in the production system and that these viruses may be transmitted from sow-to-piglet but also from piglet-to-piglet in farrowing facilities.
细小病毒（TTV）是一种单链DNA病毒，已在包括猪在内的灵长类和非灵长类动物的血清中被检测到。目前关于猪TTV感染和传播动态的信息很少。本研究的目的是深入了解母猪在将TTV传播给仔猪中的潜在作用以及哺乳期两种猪TTV基因组（TTV1和TTV2）的感染动态。使用TTV1和TTV2 PCR方法检测了44头产后1周的母猪以及215头1周龄和3周龄仔猪的血清样本。记录了母猪的胎次分布以及每头研究母猪所产仔猪（活产、死产和木乃伊化）的数量。在母猪（分别为75%和43%）以及1周龄（分别为17%和7%）和3周龄（分别为32%和12%）的仔猪中，TTV1的检测百分比高于TTV2。在母猪中观察到TTV1和TTV2共同感染的百分比（34%）高于仔猪（1周龄和3周龄时分别为2%和4%）。母猪中猪TTV基因组的检测与仔猪中的检测无关。此外，有1周龄的仔猪感染了与其母猪所检测到的不同的猪TTV基因组。在感染TTV2的母猪中，产出死产仔猪的母猪数量和每头母猪的死产仔猪平均数量往往更高；当将共同感染的母猪（TTV1和TTV2）与未共同感染的母猪进行比较时，该值显著更高。老龄胎次母猪所产1周龄仔猪中TTV1感染的百分比更高。本研究结果表明，TTV感染在生产系统中早期就会发生，并且这些病毒可能在分娩设施中从母猪传播给仔猪，也可能在仔猪之间传播。
