Kondo Takaaki, Takata Hiroshi, Matsuki Fumichika, Takiguchi Masafumi
Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
J Immunol. 2009 Feb 15;182(4):1794-8. doi: 10.4049/jimmunol.0801347.
Although IL-17-producing CD8(+) T cells (Tc17 cells) have recently been identified, the detailed information about these cells still remains unclear. In this article we describe a study investigating the phenotype and differentiation of human Tc17 cells. Human Tc17 cells were detected in a minor population of CD8(+) T cells and were predominantly found in CD27(-/+)CD28(+)CD45RA(-) memory subsets. They also expressed CCR6 and a high level of CCR5. Though most Tc17 cells produced IFN-gamma, a small part of the Tc17 cell population was IFN-gamma negative in some individuals. Analysis of the in vitro induction of Tc17 cells showed that these cells were induced from the CD27(+)CD28(+)CD45RA(+) naive subset and that they expressed the CD27(-)CD28(+)CD45RA(-) and CCR6(+) phenotype. These results together indicate that Tc17 cells have a unique phenotype and suggest that they differentiate from the same precursors that differentiate into IFN-gamma-producing CD8(+) T cells.
尽管最近已鉴定出产生白细胞介素-17的CD8(+) T细胞（Tc17细胞），但关于这些细胞的详细信息仍不清楚。在本文中，我们描述了一项研究，该研究调查了人类Tc17细胞的表型和分化情况。在一小部分CD8(+) T细胞中检测到了人类Tc17细胞，且主要存在于CD27(-/+)CD28(+)CD45RA(-)记忆亚群中。它们还表达CCR6和高水平的CCR5。虽然大多数Tc17细胞产生干扰素-γ，但在某些个体中，一小部分Tc17细胞群体为干扰素-γ阴性。对Tc17细胞体外诱导的分析表明，这些细胞是从CD27(+)CD28(+)CD45RA(+)初始亚群诱导而来的，并且它们表达CD27(-)CD28(+)CD45RA(-)和CCR6(+)表型。这些结果共同表明，Tc17细胞具有独特的表型，并表明它们与分化为产生干扰素-γ的CD8(+) T细胞的相同前体分化而来。
