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硫酸化多糖紫菜聚糖可减少HepG2细胞中载脂蛋白B100的分泌和脂质合成。

The sulfated polysaccharide porphyran reduces apolipoprotein B100 secretion and lipid synthesis in HepG2 cells.

作者信息

Inoue Nao, Yamano Naomi, Sakata Kotaro, Nagao Koji, Hama Yoichiro, Yanagita Teruyoshi

机构信息

Department of Applied Biochemistry and Food Science, Saga University, Japan.

出版信息

Biosci Biotechnol Biochem. 2009 Feb;73(2):447-9. doi: 10.1271/bbb.80688. Epub 2009 Feb 7.

DOI:10.1271/bbb.80688
PMID:19202270
Abstract

The physiological effect of porphyran, a sulfated polysaccharides from an edible red alga, was studied in human hepatoma HepG2 cells. Porphyran supplementation significantly decreased apolipoprotein B100 secretion, and the reduction was partly associated with suppression of cellular lipid synthesis in HepG2 cells. This is the first study to elucidate the mechanism of the hypolipidemic effect of porphyran.

摘要

对一种从可食用红藻中提取的硫酸化多糖——紫菜聚糖的生理效应，在人肝癌HepG2细胞中进行了研究。补充紫菜聚糖显著降低了载脂蛋白B100的分泌，且这种降低部分与HepG2细胞中细胞脂质合成的抑制有关。这是第一项阐明紫菜聚糖降血脂作用机制的研究。

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