共轭亚麻酸的9顺式、11反式、13顺式异构体可降低HepG2细胞中载脂蛋白B100的分泌及三酰甘油的合成。
The 9cis,11trans,13cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in HepG2 cells.
作者信息
Arao Keisuke, Yotsumoto Hiroaki, Han Seo-Young, Nagao Koji, Yanagita Teruyoshi
机构信息
Department of Applied Biological Sciences, Saga University, Honjyo-1, Saga 840-8502, Japan.
出版信息
Biosci Biotechnol Biochem. 2004 Dec;68(12):2643-5. doi: 10.1271/bbb.68.2643.
The physiological effects of 9cis,11trans,13cis-conjugated linolenic acid (9c,11t,13c-CLNA), one of the CLNA isomers, were studied in human hepatoma HepG2 cells. 9c,11t,13c-CLNA significantly decreased apolipoprotein B100 secretion compared with alpha-linolenic acid (alpha-LNA). The uptake of (14)C-oleate into newly synthesized cellular triacylglycerol was also decreased by 9c,11t,13c-CLNA more than by alpha-LNA treatment. This is the first study to show the hypolipidemic effect of 9c,11t,13c-CLNA.
在人肝癌HepG2细胞中研究了共轭亚麻酸异构体之一的9顺式、11反式、13顺式共轭亚麻酸（9c,11t,13c-CLNA）的生理效应。与α-亚麻酸（α-LNA）相比，9c,11t,13c-CLNA显著降低了载脂蛋白B100的分泌。9c,11t,13c-CLNA使（14）C-油酸酯摄取到新合成的细胞三酰甘油中的量比α-LNA处理的减少得更多。这是第一项显示9c,11t,13c-CLNA具有降血脂作用的研究。
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