Nishizawa Naoyuki, Togawa Tubasa, Park Kyung-Ok, Sato Daiki, Miyakoshi Yo, Inagaki Kazuya, Ohmori Norimasa, Ito Yoshiaki, Nagasawa Takashi
Department of Biological Chemistry and Food Science, Faculty of Agriculture, Iwate University, Morioka, Japan.
Biosci Biotechnol Biochem. 2009 Feb;73(2):351-60. doi: 10.1271/bbb.80589. Epub 2009 Feb 7.
Millet is an important food crop in Asia and Africa, but the health benefits of dietary millet are little known. This study defined the effects of dietary Japanese millet on diabetic mice. Feeding of a high-fat diet containing Japanese millet protein concentrate (JMP, 20% protein) to type 2 diabetic mice for 3 weeks significantly increased plasma levels of adiponectin and high-density lipoprotein cholesterol (HDL cholesterol) and decreased the levels of glucose and triglyceride as compared to control. The starch fraction of Japanese millet had no effect on glucose or adiponectin levels, but the prolamin fraction beneficially modulated plasma glucose and insulin concentrations as well as adiponectin and tumor necrosis factor-alpha gene expression. Considering the physiological significance of adiponectin and HDL cholesterol levels in type 2 diabetes, insulin resistance, and cardiovascular disease, our findings imply that dietary JMP has the potential to ameliorate these diseases.
粟是亚洲和非洲一种重要的粮食作物，但膳食粟的健康益处鲜为人知。本研究确定了食用日本粟对糖尿病小鼠的影响。与对照组相比，给2型糖尿病小鼠喂食含日本粟浓缩蛋白（JMP，蛋白质含量20%）的高脂饮食3周后，血浆脂联素和高密度脂蛋白胆固醇（HDL胆固醇）水平显著升高，血糖和甘油三酯水平降低。日本粟的淀粉部分对血糖或脂联素水平没有影响，但醇溶蛋白部分对血浆葡萄糖和胰岛素浓度以及脂联素和肿瘤坏死因子-α基因表达有有益的调节作用。考虑到脂联素和HDL胆固醇水平在2型糖尿病、胰岛素抵抗和心血管疾病中的生理意义，我们的研究结果表明，膳食JMP有改善这些疾病的潜力。
