Okazaki Yukako, Kakehi Shoko, Xu Yonghui, Tsujimoto Kazuhisa, Sasaki Masahiro, Ogawa Hiroshi, Kato Norihisa
Faculty of Human Life Sciences, Fuji Women's University, Ishikari, Japan.
Biosci Biotechnol Biochem. 2010;74(8):1534-8. doi: 10.1271/bbb.100065. Epub 2010 Aug 7.
The effect was examined of dietary sericin on the lipid and carbohydrate metabolism in rats fed with a high-fat diet. The rats were fed with a 20% beef tallow diet with or without sericin at the level of 4% for 5 weeks. The final body weight and white adipose tissue weight were unaffected by dietary manipulation. The consumption of sericin significantly reduced the serum levels of triglyceride, cholesterol, phospholipids and free fatty acids. Serum very-low-density lipoprotein (VLDL)-triglyceride, VLDL-cholesterol, low-density lipoprotein (LDL)-cholesterol and LDL-phospholipids were also significantly reduced by the sericin intake. Liver triglyceride and the activities of glucose 6-phosphate dehydrogenase and malic enzyme, the lipogenic enzymes, were also reduced by the sericin intake. Dietary sericin caused a marked elevation in serum adiponectin. The consumption of sericin suppressed the increases in plasma glucose and insulin levels after an intraperitoneal glucose injection. These results imply the usefulness of sericin for improving the lipid and carbohydrate metabolism in rats fed on a high-fat diet.
研究了日粮丝胶蛋白对高脂饮食大鼠脂质和碳水化合物代谢的影响。将大鼠喂食含20%牛脂的日粮，添加或不添加4%水平的丝胶蛋白，持续5周。日粮处理对大鼠的最终体重和白色脂肪组织重量没有影响。摄入丝胶蛋白显著降低了血清甘油三酯、胆固醇、磷脂和游离脂肪酸水平。摄入丝胶蛋白还显著降低了血清极低密度脂蛋白（VLDL）-甘油三酯、VLDL-胆固醇、低密度脂蛋白（LDL）-胆固醇和LDL-磷脂水平。摄入丝胶蛋白还降低了肝脏甘油三酯以及生脂酶葡萄糖6-磷酸脱氢酶和苹果酸酶的活性。日粮丝胶蛋白使血清脂联素显著升高。摄入丝胶蛋白抑制了腹腔注射葡萄糖后血浆葡萄糖和胰岛素水平的升高。这些结果表明丝胶蛋白对于改善高脂饮食大鼠的脂质和碳水化合物代谢是有用的。
