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珍珠粟（L.）谷物及其乙醇提取物对高脂饮食大鼠的抗高血脂、降血糖和保肝作用。

Anti-Hyperlipidemia, Hypoglycemic, and Hepatoprotective Impacts of Pearl Millet ( L.) Grains and Their Ethanol Extract on Rats Fed a High-Fat Diet.

机构信息

Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, Riyadh 11451, Saudi Arabia.

Central Research Laboratory, Female Campus, King Saud University, Riyadh 11472, Saudi Arabia.

出版信息

Nutrients. 2022 Apr 25;14(9):1791. doi: 10.3390/nu14091791.

DOI:10.3390/nu14091791
PMID:35565759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9105973/
Abstract

This study tested the anti-hyperlipidemic, hypoglycemic, hepatoprotective, and anti-inflammatory effects of whole pearl millet grain powder (MPG) and its ethanol extract (MPGethaolE) in obese rats fed a high-fat diet. The rats were divided into eight groups based on the treatments they received: control, high fat diet (HFD), HFD + MGE (25 mg/Kg), HFD + MPGethaolE (50 mg/Kg), HFD + MPGethaolE (100 mg/Kg), HFD + MPG (10%), HFD + MPG (20%), and HFD + MPG (30%). The final body weight, visceral, epididymal fat pads, and the liver weight were significantly decreased, in a dose-dependent manner, in HFD fed rats that were co-administered either the MPG powder or MPGethaolE. In the same line, serum levels of triglycerides (TGs), cholesterol (CHOL), and low-density lipoprotein-cholesterol (LDL-c), as well as fasting glucose, insulin, HOMA-IR, and serum levels of lipopolysaccharides (LPS), interleukine-6 (IL-6), interleukine-10 (IL-10), C-reactive protein (CRP), tumor necrosis factor (TNF-α), and adiponectin were progressively decreased while serum levels of high-density lipoproteins (HDL-c) were significantly increased when increasing the doses of both treatments. In conclusion, both the raw powder and ethanolic extract of MP have a comparative dose-dependent anti-obesity, hypoglycemic, hypolipidemic, anti-inflammatory, and anti-steatotic in HFD-fed rats.

摘要

本研究测试了整粒珍珠粟粉（MPG）及其乙醇提取物（MPGethaolE）对高脂饮食肥胖大鼠的降血脂、降血糖、保肝和抗炎作用。根据接受的治疗，将大鼠分为八组：对照组、高脂饮食组（HFD）、HFD+MGE（25mg/Kg）、HFD+MPGethaolE（50mg/Kg）、HFD+MPGethaolE（100mg/Kg）、HFD+MPG（10%）、HFD+MPG（20%）和 HFD+MPG（30%）。最终体重、内脏、附睾脂肪垫和肝脏重量均显著降低，且呈剂量依赖性，同时 HFD 喂养的大鼠同时给予 MPG 粉末或 MPGethaolE。同样，血清甘油三酯（TGs）、胆固醇（CHOL）和低密度脂蛋白胆固醇（LDL-c）水平以及空腹血糖、胰岛素、HOMA-IR 和血清脂多糖（LPS）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、C-反应蛋白（CRP）、肿瘤坏死因子（TNF-α）和脂联素水平逐渐降低，而高密度脂蛋白（HDL-c）水平显著升高。总之，MP 的生粉和乙醇提取物均具有剂量依赖性的抗肥胖、降血糖、降血脂、抗炎和抗脂肪变性作用，在 HFD 喂养的大鼠中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/c6aab770a975/nutrients-14-01791-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/29d45c17908b/nutrients-14-01791-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/8e86f1e6e3b6/nutrients-14-01791-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/e790446db4f8/nutrients-14-01791-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/bd8a95b32822/nutrients-14-01791-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/9abc27266e8a/nutrients-14-01791-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/4fa97d7a7712/nutrients-14-01791-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/2b6830187047/nutrients-14-01791-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/7ea1a3c2101d/nutrients-14-01791-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/c6aab770a975/nutrients-14-01791-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/29d45c17908b/nutrients-14-01791-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/8e86f1e6e3b6/nutrients-14-01791-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/e790446db4f8/nutrients-14-01791-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/bd8a95b32822/nutrients-14-01791-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/9abc27266e8a/nutrients-14-01791-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/4fa97d7a7712/nutrients-14-01791-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/2b6830187047/nutrients-14-01791-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/7ea1a3c2101d/nutrients-14-01791-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb74/9105973/c6aab770a975/nutrients-14-01791-g009.jpg

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