Martinez Julio A, Misra Nipun, Wang Yinmin, Stroeve Pieter, Grigoropoulos Costas P, Noy Aleksandr
Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94551, USA.
Nano Lett. 2009 Mar;9(3):1121-6. doi: 10.1021/nl8036504.
Nanoscale electrodes based on one-dimensional inorganic conductors could possess significant advantages for electrochemical measurements over their macroscopic counterparts in a variety of electrochemical applications. We show that the efficiency of the electrodes constructed of individual highly doped silicon nanowires greatly exceeds the efficiency of flat Si electrodes. Modification of the surfaces of the nanowire electrodes with phospholipid bilayers produces an efficient biocompatible barrier to transport of the solution redox species to the nanoelectrode surface. Incorporating functional alpha-hemolysin protein pores in the lipid bilayer results in a partial recovery of the Faradic current due to the specific transport through the protein pore. These assemblies represent a robust and versatile platform for building a new generation of highly specific biosensors and nano/bioelectronic devices.
基于一维无机导体的纳米级电极在各种电化学应用中进行电化学测量时，相比宏观对应物可能具有显著优势。我们表明，由单个高度掺杂的硅纳米线构建的电极效率大大超过平面硅电极的效率。用磷脂双层修饰纳米线电极的表面可产生一种高效的生物相容性屏障，以阻止溶液中氧化还原物质传输至纳米电极表面。在脂质双层中掺入功能性α-溶血素蛋白孔会因通过蛋白孔的特异性传输而使法拉第电流部分恢复。这些组件代表了一个强大且通用的平台，可用于构建新一代高特异性生物传感器和纳米/生物电子器件。
