SFINX——一个为临床决策支持系统设计的药物相互作用数据库。
SFINX-a drug-drug interaction database designed for clinical decision support systems.
作者信息
Böttiger Ylva, Laine Kari, Andersson Marine L, Korhonen Tuomas, Molin Björn, Ovesjö Marie-Louise, Tirkkonen Tuire, Rane Anders, Gustafsson Lars L, Eiermann Birgit
机构信息
Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, SE-14186 Stockholm, Sweden.
出版信息
Eur J Clin Pharmacol. 2009 Jun;65(6):627-33. doi: 10.1007/s00228-008-0612-5. Epub 2009 Feb 11.
OBJECTIVE
The aim was to develop a drug-drug interaction database (SFINX) to be integrated into decision support systems or to be used in website solutions for clinical evaluation of interactions.
METHODS
Key elements such as substance properties and names, drug formulations, text structures and references were defined before development of the database. Standard operating procedures for literature searches, text writing rules and a classification system for clinical relevance and documentation level were determined. ATC codes, CAS numbers and country-specific codes for substances were identified and quality assured to ensure safe integration of SFINX into other data systems. Much effort was put into giving short and practical advice regarding clinically relevant drug-drug interactions.
RESULTS
SFINX includes over 8,000 interaction pairs and is integrated into Swedish and Finnish computerised decision support systems. Over 31,000 physicians and pharmacists are receiving interaction alerts through SFINX. User feedback is collected for continuous improvement of the content.
CONCLUSION
SFINX is a potentially valuable tool delivering instant information on drug interactions during prescribing and dispensing.
目的
开发一个药物相互作用数据库（SFINX），以便集成到决策支持系统中，或用于网站解决方案以对相互作用进行临床评估。
方法
在数据库开发之前定义了诸如物质特性和名称、药物制剂、文本结构及参考文献等关键要素。确定了文献检索的标准操作规程、文本编写规则以及临床相关性和文献记录水平的分类系统。识别并确保了物质的ATC编码、CAS编号及特定国家代码的质量，以确保SFINX能安全集成到其他数据系统中。在提供有关临床相关药物相互作用的简短实用建议方面投入了大量精力。
结果
SFINX包含8000多个相互作用对，并已集成到瑞典和芬兰的计算机化决策支持系统中。超过31000名医生和药剂师通过SFINX接收相互作用警报。收集用户反馈以持续改进内容。
结论
SFINX是一个潜在的有价值工具，可在处方和配药过程中提供有关药物相互作用的即时信息。
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