Blumenthal J A, Siegel W C, Appelbaum M
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
JAMA. 1991 Oct 16;266(15):2098-104.
--To assess the effects of physical exercise training on blood pressure in patients with mild hypertension.
--Randomized controlled trial.
--Hospital-based cardiac rehabilitation program.
--Ninety-nine men and women with untreated mild hypertension (systolic blood pressure, 140 to 180 mm Hg; diastolic blood pressure, 90 to 105 mm Hg) were included in the volunteer sample.
--Subjects were randomly assigned to a 4-month program of aerobic exercise training, strength and flexibility training, or to a waiting list control group.
--The main outcome measures were systolic and diastolic blood pressures measured four times with a random zero sphygmomanometer on 3 separate days in a clinic setting.
--After 4 months of exercise training, subjects in the aerobic exercise group did not exhibit greater reductions in blood pressure than subjects in the control group. We expected a differential decline of 5 mm Hg between the aerobic exercise and waiting list control groups and found a difference of -1.0 +/- 16 mm Hg and -1.2 +/- 10 mm Hg at alpha = .05 for systolic and diastolic blood pressure, respectively.
--Moderate aerobic exercise alone should not be considered a replacement for pharmacologic therapy in nonobese patients with mild hypertension.
评估体育锻炼训练对轻度高血压患者血压的影响。
随机对照试验。
基于医院的心脏康复项目。
99名未经治疗的轻度高血压男女患者（收缩压140至180毫米汞柱；舒张压90至105毫米汞柱）被纳入志愿者样本。
受试者被随机分配到一个为期4个月的有氧运动训练、力量和柔韧性训练项目，或一个候补对照组。
主要观察指标是在临床环境中，使用随机零点血压计在3个不同日期测量4次的收缩压和舒张压。
经过4个月的运动训练，有氧运动组受试者的血压下降幅度并不比对照组受试者更大。我们预期有氧运动组和候补对照组之间的差异下降为5毫米汞柱，在α = 0.05时，收缩压和舒张压的差异分别为-1.0±16毫米汞柱和-1.2±10毫米汞柱。
对于非肥胖轻度高血压患者，仅进行适度有氧运动不应被视为药物治疗的替代方法。
