Palomo-Piñón Silvia, Gutiérrez-Rodríguez Margarita E, Díaz-Flores Margarita, Sánchez-Barrera Reyna, Valladares-Salgado Adán, Utrera-Barillas Dolores, Durán-Reyes Genoveva, Galván-Duarte Rosa E, Trinidad-Ramos Pedro, Cruz Miguel
Nephrology Department and Medical Research Unit in Biochemistry, National Medical Center, IMSS, Mexico City, Mexico.
Nephrology (Carlton). 2009 Apr;14(2):235-9. doi: 10.1111/j.1440-1797.2008.01034.x.
The DD genotype of angiotensin-converting enzyme (ACE) has been suggested as a major contributor of diabetic nephropathy in several populations. The purpose of the present study was to determine whether micro/macroalbuminuria is associated with ACE insertion/deletion (I/D) polymorphism in Mexican Mestizos with type 2 diabetes mellitus.
A total of 435 patients with type 2 diabetes mellitus, of whom 233 had albuminuria, were characterized for the ACE I/D polymorphism by the polymerase chain reaction method.
Clinical and biochemical characteristics and frequencies according to DD, ID and II genotypes in patients with and without albuminuria showed no significant differences. However, only females with micro/macroalbuminuria showed higher frequency of a DD genotype than those without albuminuria (27.9%, 21.2% and 10.5%, respectively; P <or= 0.044). In addition, female patients with macroalbuminuria without dialysis showed no significant differences with patients undergoing dialysis.
The ACE DD genotype is a risk factor for the development of renal disease in Mexican Mestizo females with type 2 diabetes, indicating a possible DD genotype-associated sex effect in renal disease.
血管紧张素转换酶(ACE)的DD基因型在一些人群中被认为是糖尿病肾病的主要促成因素。本研究的目的是确定微量/大量蛋白尿是否与墨西哥梅斯蒂索2型糖尿病患者的ACE插入/缺失(I/D)多态性相关。
共有435例2型糖尿病患者,其中233例有蛋白尿,采用聚合酶链反应法对ACE I/D多态性进行特征分析。
有蛋白尿和无蛋白尿患者根据DD、ID和II基因型的临床和生化特征及频率无显著差异。然而,仅微量/大量蛋白尿的女性患者中DD基因型频率高于无蛋白尿者(分别为27.9%、21.2%和10.5%;P≤0.044)。此外,未透析的大量蛋白尿女性患者与透析患者无显著差异。
ACE DD基因型是墨西哥梅斯蒂索2型糖尿病女性肾病发生的危险因素,表明在肾病中可能存在与DD基因型相关的性别效应。