淋巴结中的矽肺：矿工中的“金丝雀”？
Silicosis in lymph nodes: the canary in the miner?
作者信息
Cox-Ganser Jean M, Burchfiel Cecil M, Fekedulegn Desta, Andrew Michael E, Ducatman Barbara S
机构信息
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
出版信息
J Occup Environ Med. 2009 Feb;51(2):164-9. doi: 10.1097/JOM.0b013e31818f6a0f.
OBJECTIVES
To investigate evidence that lymph node silicosis can precede parenchymal silicosis.
METHODS
The study population was comprised of 264 deceased male uranium miners for whom two or more of four pathologists agreed on the presence or absence of silicosis in lymph nodes and lung parenchyma. We had work histories and silica exposure estimates.
RESULTS
Twenty percent of the miners had lymph node silicosis only, 4% had parenchymal silicosis only, and 39% had both. Silica exposure was lower for miners with lymph node silicosis only than for those with both lymph node and parenchymal silicosis. Lymph node silicosis was associated with parenchymal silicosis after adjustment for silica exposure.
CONCLUSIONS
Our results are consistent with silicosis potentially occurring in lymph nodes before the parenchyma. Lymph node damage could impair silica clearance and increase the risk for parenchymal silicosis.
目的
调查淋巴结矽肺先于实质矽肺出现的证据。
方法
研究人群包括264名已故男性铀矿工人，四名病理学家中有两名或更多人对其淋巴结和肺实质中矽肺的存在与否达成一致意见。我们有工作史和二氧化硅暴露估计值。
结果
20%的矿工仅患有淋巴结矽肺，4%的矿工仅患有实质矽肺，39%的矿工两者都有。仅患有淋巴结矽肺的矿工的二氧化硅暴露量低于同时患有淋巴结和实质矽肺的矿工。在对二氧化硅暴露进行调整后，淋巴结矽肺与实质矽肺相关。
结论
我们的结果与矽肺可能先在淋巴结而非实质中出现一致。淋巴结损伤可能会损害二氧化硅清除并增加实质矽肺的风险。
Zotero 插件