Thyssen J P, Menné T, Linneberg A, Johansen J D
National Allergy Research Centre, Department of Dermatology and Allergology, Gentofte University Hospital, Gentofte, Denmark.
Br J Dermatol. 2009 Apr;160(4):729-35. doi: 10.1111/j.1365-2133.2008.09022.x. Epub 2009 Feb 4.
Contact sensitization to fragrance mix (FM) I and Myroxylon pereirae (MP) is common among European patients with dermatitis. Recently, FM II was included in the European baseline series as an additional marker of fragrance sensitization.
This literature review aims to assess the prevalence of fragrance sensitization in the general population, and to suggest how future population-based studies and questionnaires should be constructed, better to assess the prevalence and burden of fragrance sensitization. This is of relevance as it is often difficult to establish causality in biological systems.
A systematic review of the literature was carried out by searching Pubmed-Medline, Biosis and contact dermatitis textbooks.
Nineteen studies were identified, of which 13 were performed among adults. Sample sizes varied between 82 and 2545 tested subjects, and 11 648 subjects were tested in total. The median prevalence of FM and MP sensitization among adults was 2.3% (women, 1.7%; men, 1.3%) and 1.1% (women, 1.4%; men, 0%), respectively.
Based on the reliability of patch test data from the general population and exposure data obtained from patients with dermatitis, the prevalence and burden of fragrance sensitization in the general population is significant.
在欧洲的皮炎患者中，对香料混合物（FM）I和秘鲁香脂（MP）的接触致敏很常见。最近，FM II被纳入欧洲基线系列，作为香料致敏的另一个标志物。
本综述旨在评估普通人群中香料致敏的患病率，并就未来基于人群的研究和问卷应如何构建提出建议，以便更好地评估香料致敏的患病率和负担。这很重要，因为在生物系统中往往难以确定因果关系。
通过检索Pubmed-Medline、Biosis和接触性皮炎教科书对文献进行系统综述。
共鉴定出19项研究，其中13项在成年人中进行。样本量在82至2545名受试对象之间，总共测试了11648名对象。成年人中FM和MP致敏的中位患病率分别为2.3%（女性为1.7%；男性为1.3%）和1.1%（女性为1.4%；男性为0%）。
基于普通人群斑贴试验数据的可靠性以及从皮炎患者获得的暴露数据，普通人群中香料致敏的患病率和负担是显著的。
