人类巨细胞病毒UL112 - 113基因座可激活完整的卡波西肉瘤相关疱疹病毒裂解复制周期。
The human cytomegalovirus UL112-113 locus can activate the full Kaposi's sarcoma-associated herpesvirus lytic replication cycle.
作者信息
Wells Richard, Stensland Laurence, Vieira Jeffrey
机构信息
Department of Laboratory Medicine, University of Washington, Seattle, Washington 98109, USA.
出版信息
J Virol. 2009 May;83(9):4695-9. doi: 10.1128/JVI.02241-08. Epub 2009 Feb 11.
Abstract
Human cytomegalovirus (HCMV) infection of a cell containing latent Kaposi's sarcoma-associated herpesvirus (KSHV) results in the activation of KSHV lytic replication and the production of infectious virus. In this study, we examined the HCMV genes identified as having a role in the activation of HCMV early genes for their ability to activate KSHV lytic replication. It was found that the UL112-113 locus was able to activate the complete KSHV lytic cycle, while the UL122-123 locus, encoding the IE1 and IE2 proteins, known to be strong transactivators, did not.
摘要
人类巨细胞病毒（HCMV）感染含有潜伏性卡波西肉瘤相关疱疹病毒（KSHV）的细胞会导致KSHV裂解复制的激活以及传染性病毒的产生。在本研究中，我们检测了被确定在HCMV早期基因激活中起作用的HCMV基因激活KSHV裂解复制的能力。结果发现，UL112 - 113基因座能够激活完整的KSHV裂解周期，而编码已知为强反式激活因子的IE1和IE2蛋白的UL122 - 123基因座则不能。
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