Duran Ismet, Sengun Abdulkadir, Hadimli Hasan Huseyin, Ulker Mustafa
Assoc. Prof., Selcuk University, Faculty of Dentistry, Department of Periodontology.
Eur J Dent. 2008 Jan;2(1):43-7.
Desensitizers contribute to better clinical results by reducing the rate of cervical dentin sensitivity. However, information on their antibacterial effect is limited. This study examined the antibacterial activities of a triclosan containing (Seal & Protect), a benzalconium containing desensitizer (Micro Prime), a fluoride containing prophilaxy paste (Sultan Desensitizer), two fluoride containing varnishes (Cavity Shealth and Ultra EZ), and a dentin bonding primer (All Bond).
The test materials were inserted in the wells of Muller Hinton agar plates inoculated with Streptococcus mutans, Streptococcus salivarious, Staphylococcus aureus, Streptococcus faecalis and Pseudomonas aeruginosa. The diameters of the inhibition zones produced around the materials were measured after 24 h of incubation. The results were analyzed by the Kruskal Wallis one way ANOVA and the Mann-Whitney tests at a significance level of P<.05.
Micro Prime Desensitizer containing benzalkonium chloride had the highest antibacterial effectiveness compared to other desensitizers used in this study. In addition, triclosan containing Seal & Protect and acidic components containing All Bond showed very high antibacterial efficacy. On the other hand, fluoride within both varnishes had little antibacterial effectiveness. However a fluoride component in a paste (Sultan Desensitizer) showed very high bactericidal effect.
All desensitizers except fluoride varnishes showed various degrees of antibacterial effect against the bacteria tested in this study. If antibacterial effect is also required from the desensitizers' clinicians should avoid use of varnishes.
脱敏剂通过降低牙颈部牙本质敏感率有助于获得更好的临床效果。然而，关于其抗菌作用的信息有限。本研究检测了一种含三氯生的脱敏剂（Seal & Protect）、一种含苯扎氯铵的脱敏剂（Micro Prime）、一种含氟预防性糊剂（Sultan Desensitizer）、两种含氟 varnishes（Cavity Shealth 和 Ultra EZ）以及一种牙本质粘结剂（All Bond）的抗菌活性。
将测试材料插入接种了变形链球菌、唾液链球菌、金黄色葡萄球菌、粪肠球菌和铜绿假单胞菌的穆勒 - 欣顿琼脂平板孔中。孵育 24 小时后测量材料周围产生的抑菌圈直径。结果采用 Kruskal Wallis 单因素方差分析和 Mann - Whitney 检验进行分析，显著性水平为 P <.05。
与本研究中使用的其他脱敏剂相比，含苯扎氯铵的 Micro Prime 脱敏剂具有最高的抗菌效果。此外，含三氯生的 Seal & Protect 和含酸性成分的 All Bond 显示出非常高的抗菌功效。另一方面，两种 varnishes 中的氟几乎没有抗菌效果。然而，一种糊剂（Sultan Desensitizer）中的氟成分显示出非常高的杀菌效果。
除氟 varnishes 外，所有脱敏剂对本研究中测试的细菌均显示出不同程度的抗菌作用。如果临床医生也需要脱敏剂具有抗菌作用，应避免使用 varnishes。
