Beving H, Malmgren R, Petre'n S, Vesterberg O
Department of Experimental Surgery, Karolinska Hospital, Stockholm, Sweden.
J Soc Occup Med. 1991 Autumn;41(3):102-6. doi: 10.1093/occmed/41.3.102.
Haematological parameters, iso-transferrin ratio in plasma and serotonin uptake in platelets were studied in 10 men (age range 21-54 years) with occupational long-term, low level exposure to vapours from epoxy paints. The control group consisted of 10 healthy men (age range 20-48 years) not occupationally exposed to chemicals or organic solvents. The mean cellular volume of erythrocytes was significantly higher for the house painters than the controls (p less than 0.05). The plasma concentration of iso-transferrin with isoelectric point 5.7 (Tf5.7) and the ratio between Tf5.7 and total transferrin (Tftot) were significantly higher in the exposed group (p less than 0.05). The uptake of serotonin in platelets (Vmax) from the exposed workers was significantly lower than the values for the controls (p less than 0.01). The results indicate an association between the observed biological effects and the chemical exposure, and we speculate that this is caused by changes in structure and function of the cell membranes.
对10名长期职业性低水平接触环氧漆蒸汽的男性（年龄范围21 - 54岁）的血液学参数、血浆中异铁传递蛋白比率以及血小板中血清素摄取情况进行了研究。对照组由10名未职业性接触化学物质或有机溶剂的健康男性（年龄范围20 - 48岁）组成。房屋油漆工红细胞的平均细胞体积显著高于对照组（p < 0.05）。暴露组中，等电点为5.7的异铁传递蛋白（Tf5.7）的血浆浓度以及Tf5.7与总铁传递蛋白（Tftot）的比率显著更高（p < 0.05）。暴露工人血小板中血清素的摄取量（Vmax）显著低于对照组（p < 0.01）。结果表明所观察到的生物学效应与化学物质暴露之间存在关联，我们推测这是由细胞膜结构和功能的变化引起的。
