Ashyraliyev Maksat, Fomekong-Nanfack Yves, Kaandorp Jaap A, Blom Joke G
Centrum voor Wiskunde en Informatica, Amsterdam, The Netherlands.
FEBS J. 2009 Feb;276(4):886-902. doi: 10.1111/j.1742-4658.2008.06844.x.
Mathematical models of biological processes have various applications: to assist in understanding the functioning of a system, to simulate experiments before actually performing them, to study situations that cannot be dealt with experimentally, etc. Some parameters in the model can be directly obtained from experiments or from the literature. Others have to be inferred by comparing model results to experiments. In this minireview, we discuss the identifiability of models, both intrinsic to the model and taking into account the available data. Furthermore, we give an overview of the most frequently used approaches to search the parameter space.
有助于理解系统的功能，在实际进行实验之前模拟实验，研究无法通过实验处理的情况等。模型中的一些参数可以直接从实验或文献中获得。其他参数则必须通过将模型结果与实验进行比较来推断。在这篇小型综述中，我们讨论了模型的可识别性，包括模型本身的可识别性以及考虑可用数据后的可识别性。此外，我们概述了搜索参数空间最常用的方法。
