Spencer Clayton Glen, Campbell Phillip M, Buschang Peter H, Cai John, Honeyman Allen L
Angle Orthod. 2009 Mar;79(2):317-22. doi: 10.2319/011408-19.1.
To test the null hypothesis that the addition of zinc oxide (ZnO) has no effect on the antimicrobial benefits and shear bond strength of a light-cured resin-modified glass ionomer.
ZnO was added to Fuji Ortho LC to create mixtures of 13% ZnO and 23.1% ZnO. Specimen discs of the modified bonding agent were incubated with Streptococcus mutans for 48 hours in a disc diffusion assay that was used to measure zones of bacterial inhibition. In addition, brackets were bonded to bovine deciduous incisors with the modified bonding agents, and shear bond strength was evaluated with a universal testing machine.
The modified samples showed that antimicrobial activity increased as the concentration of ZnO increased. There were significant differences (P < .05) in antimicrobial activity. Post hoc tests showed that the antibacterial effects were 1.6 times greater with 23.1% ZnO than with 13% ZnO. There was no difference between Transbond and 0% ZnO (the negative control). After 1 month of daily rinsing, the antibacterial effects of 23.1% ZnO and 13% ZnO decreased 65% and 77%, respectively, but both maintained significant effects over the negative controls. There were no significant differences (P = .055) in shear bond strength between any of the mixture comparisons.
The incorporation of ZnO into Fuji Ortho LC added antimicrobial properties to the original compound without significantly altering the shear bond strength. ZnO holds potential for preventing decalcification associated with orthodontic treatment.
检验零假设，即添加氧化锌（ZnO）对光固化树脂改性玻璃离子水门汀的抗菌效果和剪切粘结强度没有影响。
将ZnO添加到Fuji Ortho LC中，制成含13%ZnO和23.1%ZnO的混合物。在纸片扩散试验中，将改性粘结剂的样本圆盘与变形链球菌一起孵育48小时，以测量细菌抑制圈。此外，用改性粘结剂将托槽粘结到牛乳牙切牙上，并用万能试验机评估剪切粘结强度。
改性样本表明，抗菌活性随ZnO浓度的增加而增强。抗菌活性存在显著差异（P <.05）。事后检验表明，23.1%ZnO的抗菌效果比13%ZnO高1.6倍。Transbond与0%ZnO（阴性对照）之间没有差异。在每日冲洗1个月后，23.1%ZnO和13%ZnO的抗菌效果分别下降了65%和77%，但两者对阴性对照均保持显著效果。在任何混合物比较中，剪切粘结强度均无显著差异（P = 0.055）。
将ZnO掺入Fuji Ortho LC中，在不显著改变剪切粘结强度的情况下，为原化合物增添了抗菌性能。ZnO在预防正畸治疗相关脱矿方面具有潜力。
