Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, Republic of Korea.
Department of Dental Hygiene, Division of Health Science, Baekseok University, Cheonan, Republic of Korea.
Sci Rep. 2023 Oct 18;13(1):17763. doi: 10.1038/s41598-023-44490-z.
Dental composite resins are widely used in dental restorations. However, their clinical application is limited by the occurrence of secondary caries. Strontium-modified phosphate-based glass (Sr-PBG) is a material known to have a sustainable bacterial resistance effect. The mechanical properties (in particular, flexural strength, modulus of elasticity, and hardness) of dental materials determine their function. Therefore, this study aimed to investigate the mechanical and ion-releasing properties as well as the sustainable bacterial resistance effect of bioactive resin composites containing Sr-PBG. The data were analyzed by ANOVA and Tuckey's tests (p < 0.05). We incorporated a Sr-PBG microfiller at 3, 6, and 9 wt.% concentrations into a commercially available composite resin and investigated the mechanical properties (flexural strength, elastic modulus, and micro hardness), ion release characteristics, and color of the resultant resins. In addition, we examined the antibacterial effects of the composite resins against Streptococcus mutans (S. mutans). The mechanical properties of the Sr-PBG groups differed only slightly from those of the control group (p > 0.05). However, the optical density at 600 nm of S. mutans incubated on the experimental group was significantly lower compared to that observed with the control (p < 0.05) both before and after thermocycling between 5 and 55 ℃ for 850 cycles (dwell time: 45 s). Therefore, strontium-modified resin materials exhibited a sustainable bacterial resistance effect in vitro while maintaining some of the mechanical properties of ordinary acrylic resins.
牙科复合树脂广泛应用于牙科修复。然而，其临床应用受到继发龋的限制。锶改性磷酸盐基玻璃（Sr-PBG）是一种具有持续抗菌效果的材料。牙科材料的机械性能（尤其是弯曲强度、弹性模量和硬度）决定了其功能。因此，本研究旨在研究含有 Sr-PBG 的生物活性树脂复合材料的机械和离子释放性能以及持续的抗菌效果。数据分析采用方差分析和 Tukey 检验（p < 0.05）。我们将 Sr-PBG 微填料以 3%、6%和 9%wt.%的浓度掺入市售复合树脂中，研究了所得树脂的机械性能（弯曲强度、弹性模量和显微硬度）、离子释放特性和颜色，以及复合树脂对变形链球菌（S. mutans）的抗菌效果。Sr-PBG 组的机械性能与对照组仅略有差异（p > 0.05）。然而，在 5 至 55°C 之间热循环 850 次（停留时间：45 秒）前后，与对照组相比，在实验组上孵育的 S. mutans 的 600nm 处的光密度明显较低（p < 0.05）。因此，锶改性树脂材料在体外表现出持续的抗菌效果，同时保持了普通丙烯酸树脂的部分机械性能。
