Ahn Sug-Joon, Lee Shin-Jae, Kook Joong-Ki, Lim Bum-Soon
Dental Research Institute and Department of Orthodontics, College of Dentistry, Seoul National University, 28-22 Yunkeun-Dong, Chongro-Ku, Seoul 110-768, Republic of Korea.
Dent Mater. 2009 Feb;25(2):206-13. doi: 10.1016/j.dental.2008.06.002. Epub 2008 Jul 15.
Experimental composite adhesives (ECAs) containing silica nanofillers and silver nanoparticles were compared with two conventional adhesives (composite and resin-modified glass ionomer [RMGI]) to analyze surface characteristics, physical properties and antibacterial activities against cariogenic streptococci.
Surface roughness and surface free energy (SFE) characteristics were measured using confocal laser scanning microscopy and the sessile drop method. Shear bond strength and bond failure interface were analyzed to compare the physical properties. Antimicrobial activities were analyzed by a bacterial adhesion assay, a disk diffusion test, and an optical density measurement of bacterial suspension containing each adhesive.
ECAs had rougher surfaces than conventional adhesives due to the addition of silver nanoparticles. ECAs had more similar SFE characteristics to composite than to RMGI. Bacterial adhesion to ECAs was less than to conventional adhesives, which was not influenced by saliva coating. Bacterial suspension containing ECAs showed slower bacterial growth than those containing conventional adhesives. There was no significant difference in shear bond strength and bond failure interface between ECAs and conventional adhesives.
This study suggests that ECAs can help prevent enamel demineralization around their surfaces without compromising physical properties.
将含有二氧化硅纳米填料和银纳米颗粒的实验性复合粘合剂（ECAs）与两种传统粘合剂（复合树脂和树脂改性玻璃离子水门汀[RMGI]）进行比较，以分析其表面特性、物理性能以及对致龋链球菌的抗菌活性。
使用共聚焦激光扫描显微镜和静滴法测量表面粗糙度和表面自由能（SFE）特性。分析剪切粘结强度和粘结失败界面以比较物理性能。通过细菌粘附试验、纸片扩散试验以及对含有每种粘合剂的细菌悬液进行光密度测量来分析抗菌活性。
由于添加了银纳米颗粒，ECAs的表面比传统粘合剂更粗糙。与RMGI相比，ECAs的SFE特性与复合树脂更相似。细菌对ECAs的粘附少于对传统粘合剂的粘附，且不受唾液涂层的影响。含有ECAs的细菌悬液的细菌生长比含有传统粘合剂的悬液慢。ECAs与传统粘合剂之间的剪切粘结强度和粘结失败界面没有显著差异。
本研究表明，ECAs可以帮助预防其表面周围的牙釉质脱矿，而不会损害物理性能。
