伤口感染患者对铜绿假单胞菌抗体反应的特征分析。

Characterization of antibody response to Pseudomonas aeruginosa in patients with wound infections.

作者信息

Trafny E A, Grzybowski J, Patzer J, Popiel D, Wrembel-Wargocka J, Dzierzanowska D, Zawistowska-Marciniak I, Kobus K

机构信息

Department of Microbiology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.

出版信息

Microbiol Immunol. 1991;35(6):435-42. doi: 10.1111/j.1348-0421.1991.tb01574.x.

DOI:10.1111/j.1348-0421.1991.tb01574.x

PMID:1921760

Abstract

ELISA was used to measure the amount and avidity of IgG antibodies to exotoxin A (ExA) and 7 Fisher's immunotypes of lipopolysaccharide (LPS) in the sera of 13 patients with mild or moderate Pseudomonas aeruginosa infections. Changes in the specificity of tested sera during the course of infection were demonstrated. A statistically significant increase was seen in the amount and avidity of the antibodies to ExA in a majority of the sera, and an increase was seen in amount of antibodies to LPS immunotype 4 in the sera of patients with moderate infections.

摘要

采用酶联免疫吸附测定法（ELISA）检测了13例轻度或中度铜绿假单胞菌感染患者血清中抗外毒素A（ExA）的IgG抗体量及亲和力，以及7种费舍尔脂多糖（LPS）免疫型。结果显示了感染过程中受试血清特异性的变化。大多数血清中抗ExA抗体的量和亲和力有统计学意义的增加，中度感染患者血清中抗LPS免疫型4抗体的量有所增加。