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未接受治疗的HIV感染者中HIV-1 RNA水平与CD4细胞计数之间的关联。

Association between HIV-1 RNA level and CD4 cell count among untreated HIV-infected individuals.

作者信息

Lima Viviane D, Fink Valeria, Yip Benita, Hogg Robert S, Harrigan P Richard, Montaner Julio S G

机构信息

British Columbia Centre for Excellence in HIV/AIDS, St Paul's Hospital, 667-1081 Burrard St, Vancouver, BC, V6Z 1Y6 Canada.

出版信息

Am J Public Health. 2009 Apr;99 Suppl 1(Suppl 1):S193-6. doi: 10.2105/AJPH.2008.137901. Epub 2009 Feb 12.

DOI:10.2105/AJPH.2008.137901
PMID:19218172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2724944/
Abstract

OBJECTIVES

We examined the significance of plasma HIV-1 RNA levels (or viral load alone) in predicting CD4 cell decline in untreated HIV-infected individuals.

METHODS

Data were obtained from the British Columbia Centre for Excellence in HIV/AIDS. Participants included all residents who ever had a viral load determination in the province and who had never taken antiretroviral drugs (N = 890). We analyzed a total of 2074 viral load measurements and 2332 CD4 cell counts. Linear mixed-effects models were used to predict CD4 cell decline over time.

RESULTS

Longitudinal viral load was strongly associated with CD4 cell decline over time; an average of 1 log(10) increase in viral load was associated with a 55-cell/mm(3) decrease in CD4 cell count.

CONCLUSIONS

Our results support the combined use of CD4 cell count and viral load as prognostic markers in HIV-infected individuals before the introduction of antiretroviral therapy.

摘要

目的

我们研究了血浆HIV-1 RNA水平（或仅病毒载量）在预测未接受治疗的HIV感染者CD4细胞下降方面的意义。

方法

数据来自不列颠哥伦比亚省卓越HIV/AIDS中心。参与者包括该省所有曾进行过病毒载量测定且从未服用过抗逆转录病毒药物的居民（N = 890）。我们共分析了2074次病毒载量测量值和2332次CD4细胞计数。采用线性混合效应模型预测CD4细胞随时间的下降情况。

结果

纵向病毒载量与CD4细胞随时间的下降密切相关；病毒载量平均每增加1 log(10)，CD4细胞计数就会减少55个细胞/mm³。

结论

我们的结果支持在引入抗逆转录病毒治疗之前，将CD4细胞计数和病毒载量联合用作HIV感染者的预后标志物。

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