创伤弧菌人畜共患病血清型中的自发喹诺酮耐药性。
Spontaneous quinolone resistance in the zoonotic serovar of Vibrio vulnificus.
作者信息
Roig Francisco J, Llorens A, Fouz B, Amaro C
机构信息
Departamento de Microbiología, Facultad de Biología, Universidad de Valencia, Valencia, Spain.
出版信息
Appl Environ Microbiol. 2009 Apr;75(8):2577-80. doi: 10.1128/AEM.02921-08. Epub 2009 Feb 13.
Abstract
This work demonstrates that Vibrio vulnificus biotype 2, serovar E, an eel pathogen able to infect humans, can become resistant to quinolone by specific mutations in gyrA (substitution of isoleucine for serine at position 83) and to some fluoroquinolones by additional mutations in parC (substitution of lysine for serine at position 85). Thus, to avoid the selection of resistant strains that are potentially pathogenic for humans, antibiotics other than quinolones must be used to treat vibriosis on farms.
摘要
这项研究表明，创伤弧菌生物型2、血清型E，一种能够感染人类的鳗鱼病原体，可通过gyrA基因的特定突变（第83位丝氨酸被异亮氨酸取代）对喹诺酮产生耐药性，并通过parC基因的额外突变（第85位丝氨酸被赖氨酸取代）对某些氟喹诺酮产生耐药性。因此，为避免选择对人类具有潜在致病性的耐药菌株，必须使用喹诺酮类以外的抗生素来治疗养殖场的弧菌病。
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