Seres Imola, Unoka Zsolt, Kéri Szabolcs
Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.
Neuroreport. 2009 Mar 4;20(4):388-92. doi: 10.1097/WNR.0b013e328324eb4d.
Trust and cooperation are essential features of human interpersonal transactions. Recent evidence suggests that these processes are related to brain areas implicated in social decision-making. These novel data provide a unique opportunity to characterize psychopathological conditions in which trust and cooperation are potentially impaired. Using economic games, independent investigations revealed that trust and cooperation are disrupted in patients with borderline personality disorder who have severe difficulties in their personal relationships and exhibit abnormal emotion regulation. Data from functional neuroimaging indicated that the abnormal activation of the anterior insula might be a key factor during these processes, together with the cingulate cortex and the amygdala.
信任与合作是人际互动的基本特征。近期证据表明，这些过程与参与社会决策的脑区相关。这些新数据提供了一个独特的机会来描述信任与合作可能受损的精神病理状况。通过经济博弈，独立研究发现，边缘型人格障碍患者的信任与合作受到破坏，这类患者在人际关系中存在严重困难且表现出异常的情绪调节。功能神经影像学数据表明，在前岛叶异常激活的同时，扣带回皮质和杏仁核可能是这些过程中的关键因素。
