二磷酸腺苷核糖基化组蛋白
Adenosine diphosphate ribosylated histones.
作者信息
Ord M G, Stocken L A
出版信息
Biochem J. 1977 Mar 1;161(3):583-92. doi: 10.1042/bj1610583.
Abstract
When rat liver nuclei were incubated with [adenine-3H]NAD, besides histone 1, histone 2A and especially histone 2B accepted 3H radioactivity. 3H radioactivity was also found on the non-histone proteins and on the small amounts of histones 1 and 3 released into the supernatant during incubation. [14C]Adenine uptake in vivo by liver and thymus nuclei showed radioactivity in histones 1 and 3. After digestion with Pronase and leucine aminopeptidase 14C- or 32P-labelled histone 3 released a serine phosphate-containing nucleotide, which on acid hydrolysis yielded ADP-ribose and serine phosphate. Serine phosphate was also found in the material from the nucleotide peaks from histones 2A and 2B. ADP-ribosylated histones 1 and 3 were more easily released from nuclei than their unmodified forms and showed higher [32P]Pi and [3H]lysine uptakes in vivo [Ord & Stocken (1975) FEBS Meet. Proc. 34, 113-125].
摘要
当用[腺嘌呤 - ³H]NAD孵育大鼠肝细胞核时，除组蛋白1外，组蛋白2A尤其是组蛋白2B接受了³H放射性。在非组蛋白以及孵育过程中释放到上清液中的少量组蛋白1和3上也发现了³H放射性。肝和胸腺细胞核在体内对[¹⁴C]腺嘌呤的摄取显示组蛋白1和3中有放射性。用链霉蛋白酶和亮氨酸氨肽酶消化后，¹⁴C或³²P标记的组蛋白3释放出一种含丝氨酸磷酸的核苷酸，酸水解后产生ADP - 核糖和丝氨酸磷酸。在组蛋白2A和2B的核苷酸峰的物质中也发现了丝氨酸磷酸。ADP - 核糖基化的组蛋白1和3比未修饰形式更容易从细胞核中释放出来，并且在体内显示出更高的[³²P]Pi和[³H]赖氨酸摄取量[奥德和斯托肯（1975年）欧洲生物化学学会会议论文集34，113 - 125]。
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