Alonso-Monge R, Román E, Arana D M, Pla J, Nombela C
Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
Clin Microbiol Infect. 2009 Jan;15 Suppl 1:17-9. doi: 10.1111/j.1469-0691.2008.02690.x.
Cells need to adapt to the external environment in order to survive. Signal transduction pathways are crucial mechanisms that allow cells to sense and respond to extracellular stimuli. Among the signal transduction pathways, we point out the cascades mediated by mitogen-activated protein kinases (MAPKs). The MAPKs are conserved from yeast to human and play relevant roles in the physiology of the cell. In pathogenic fungi these MAPK pathways control virulence factors. This review describes the MAPK cascades described in Candida albicans, the most frequently isolated fungus, from fungal systemic infections among individuals in developed countries.
细胞需要适应外部环境以存活。信号转导通路是使细胞能够感知并响应细胞外刺激的关键机制。在信号转导通路中，我们指出由丝裂原活化蛋白激酶（MAPK）介导的级联反应。MAPK从酵母到人类都是保守的，并且在细胞生理学中发挥重要作用。在致病真菌中，这些MAPK通路控制毒力因子。本综述描述了白色念珠菌中所述的MAPK级联反应，白色念珠菌是发达国家个体真菌全身感染中最常分离出的真菌。
