13只狒狒的自发性鳞状细胞癌、蜘蛛猴的首例报告以及非人灵长类动物文献综述
Spontaneous squamous cell carcinomas in 13 baboons, a first report in a spider monkey, and a review of the non-human primate literature.
作者信息
Haddad Jamie L, Dick Edward J, Guardado-Mendoza Rodolfo, Hubbard Gene B
机构信息
Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX 76227-5301, USA.
出版信息
J Med Primatol. 2009 Jun;38(3):175-86. doi: 10.1111/j.1600-0684.2009.00338.x.
BACKGROUND
Squamous cell carcinoma (SCC) is a neoplastic proliferation of epithelial cells undergoing squamous differentiation and represents a diagnostic challenge in non-human primates (NHP), especially in baboons with perineal SCC.
METHODS
Fourteen SCC (13 baboons, 1 spider monkey) were identified over a 20-year period. A literature search identified 86 additional published cases of spontaneous NHP SCC.
RESULTS
Squamous cell carcinoma was most commonly reported in macaques, baboons, marmosets, and squirrel monkeys. Metastasis occurred in 23%, of NHP. The most frequently reported primary locations were the oral cavity, integument, esophagus, and cervix-uterus. Perineal SCC occurred mainly in baboons. All reported SCC in marmosets occurred in the head. Nasal cavity SCC was only reported in male marmosets. All reported pulmonary SCC occurred in males, mostly in tree shrews.
CONCLUSIONS
Squamous cell carcinoma is a common neoplasm in NHP and exhibits species differences. NHPs may provide a useful SCC animal model.
背景
鳞状细胞癌（SCC）是上皮细胞发生鳞状分化的肿瘤性增殖，在非人类灵长类动物（NHP）中是一项诊断挑战，尤其是在患有会阴SCC的狒狒中。
方法
在20年期间鉴定出14例SCC（13只狒狒，1只蜘蛛猴）。文献检索又发现了另外86例已发表的自发性NHP SCC病例。
结果
鳞状细胞癌最常报道于猕猴、狒狒、狨猴和松鼠猴。23%的NHP发生转移。最常报道的原发部位是口腔、体表、食管和子宫颈。会阴SCC主要发生于狒狒。所有报道的狨猴SCC均发生在头部。鼻腔SCC仅在雄性狨猴中报道。所有报道的肺部SCC均发生于雄性，主要是树鼩。
结论
鳞状细胞癌是NHP中的常见肿瘤，且存在物种差异。NHP可能提供一个有用的SCC动物模型。
Zotero 插件