Ito Hiroshi T, Schuman Erin M
Division of Biology, California Institute of Technology Pasadena, CA, USA.
Front Neurosci. 2008 Dec 15;2(2):138-44. doi: 10.3389/neuro.01.027.2008. eCollection 2008 Dec.
The brain uses a strategy of labor division, which may allow it to accomplish more elaborate and complicated tasks, but in turn, imposes a requirement for central control to integrate information among different brain areas. Anatomically, the divergence of long-range neuromodulator projections appears well-suited to coordinate communication between brain areas. Oscillatory brain activity is a prominent feature of neural transmission. Thus, the ability of neuromodulators to modulate signal transmission in a frequency-dependent manner adds an additional level of regulation. Here, we review the significance of frequency-dependent signal modulation in brain function and how a neuronal network can possess such properties. We also describe how a neuromodulator, dopamine, changes frequency-dependent signal transmission, controlling information flow from the entorhinal cortex to the hippocampus.
大脑采用分工策略，这或许能使其完成更精细复杂的任务，但反过来也对中央控制提出了要求，以便整合不同脑区之间的信息。从解剖学角度来看，长程神经调质投射的发散似乎非常适合协调脑区之间的通信。振荡性脑活动是神经传递的一个显著特征。因此，神经调质以频率依赖方式调节信号传递的能力增加了一层额外的调控。在此，我们综述频率依赖信号调制在脑功能中的重要性，以及神经网络如何具备这样的特性。我们还描述了一种神经调质多巴胺如何改变频率依赖信号传递，控制从内嗅皮质到海马体的信息流。
