抗肿瘤药。570. 从海洋芽孢杆菌中分离和结构鉴定杆菌菌素 1 和 2。
Antineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris.
机构信息
Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, P.O. Box 871604, Tempe, Arizona 85287-1604, USA.
出版信息
J Nat Prod. 2009 Mar 27;72(3):366-71. doi: 10.1021/np800603u.
Abstract
Two new cyclodepsipeptides designated bacillistatins 1 (1) and 2 (2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI(50)'s of 10(-4)-10(-5) microg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.
摘要
两种新的环二肽被命名为杆菌霉素 1（1）和 2（2），它们是从从南智利太平洋海域的一只螃蟹体内的样本中分离出来的。每个由 12 个单元组成的环二肽强烈抑制人类癌细胞系的生长，GI（50）值为 10（-4）-10（-5）μg/ml，而且每个化合物对耐抗生素的肺炎链球菌都有活性。结构是通过 X 射线衍射和质量及二维 NMR 波谱分析以及化学降解的结合来阐明的。
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