源自海洋真菌奥氏曲霉的与刺孢曲菌素和二氢刺孢酮相关的五酮化合物。

Pentaketides relating to aspinonene and dihydroaspyrone from a marine-derived fungus, Aspergillus ostianus.

作者信息

Kito Keijiro, Ookura Ryuhei, Yoshida Sanae, Namikoshi Michio, Ooi Takashi, Kusumi Takenori

机构信息

Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan.

出版信息

J Nat Prod. 2007 Dec;70(12):2022-5. doi: 10.1021/np070301n. Epub 2007 Nov 10.

DOI:10.1021/np070301n

PMID:17994702

Abstract

Three new pentaketides, aspinotriols A ( 1) and B ( 3) and aspinonediol ( 5), were isolated together with two known compounds, aspinonene ( 7) and dihydroaspyrone ( 9), from the marine fungus Aspergillus ostianus strain 01F313, which was collected in Pohnpei and cultured with bromine-modified artificial seawater. The structures of the new compounds were determined by spectroscopic analyses including 1D and 2D NMR. Although 1 and 3 are diastereomers, they show nearly superimposable (1)H and (13)C NMR spectra. The absolute configurations of compounds 1, 3, 5, and 9 were elucidated by the modified Mosher's method.

摘要

从采自波纳佩岛并用溴改性人工海水培养的海洋真菌曲霉属菌株01F313中，分离出三种新的五酮类化合物，即曲霉三醇A（1）、曲霉三醇B（3）和曲霉二醇（5），同时还分离出两种已知化合物，即曲霉烯（7）和二氢曲霉酮（9）。通过包括一维和二维核磁共振在内的光谱分析确定了新化合物的结构。虽然1和3是非对映异构体，但它们的氢核磁共振和碳核磁共振谱几乎重叠。通过改进的莫舍尔方法阐明了化合物1、3、5和9的绝对构型。