Pasarica Magdalena, Xie Hui, Hymel David, Bray George, Greenway Frank, Ravussin Eric, Smith Steven R
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Diabetes Care. 2009 May;32(5):900-2. doi: 10.2337/dc08-2240. Epub 2009 Feb 19.
We hypothesized that, compared with obese subjects, patients with type 2 diabetes have a lower total adipocyte number with fewer small adipocytes.
Abdominal subcutaneous adipose tissue was obtained from lean and obese subjects with or without type 2 diabetes matched for BMI. Adipocyte size was measured by osmium fixation and sizing/counting in a Coulter counter. Adipocyte size and number subdistributions (small, medium, large, and very large) were determined.
Compared with obese subjects, type 2 diabetic patients had larger mean adipocyte size and 67% bigger very large adipocytes; the total adipocyte number was lower, but the fraction of small adipocytes was increased by 27%.
Total adipocyte cellularity is lower in type 2 diabetic subjects than in obese subjects. We found no evidence for depletion of small adipocytes in patients with type 2 diabetes. This suggests the presence of a defect in early maturation of adipocytes in patients with type 2 diabetes.
我们推测，与肥胖受试者相比，2型糖尿病患者的脂肪细胞总数更低，小脂肪细胞数量更少。
从体重指数（BMI）匹配的有或无2型糖尿病的瘦人和肥胖受试者中获取腹部皮下脂肪组织。通过锇固定并在库尔特计数器中进行大小测量/计数来测定脂肪细胞大小。确定脂肪细胞大小和数量的亚分布（小、中、大、非常大）。
与肥胖受试者相比，2型糖尿病患者的平均脂肪细胞大小更大，非常大的脂肪细胞大67%；脂肪细胞总数更低，但小脂肪细胞的比例增加了27%。
2型糖尿病患者的脂肪细胞总数低于肥胖受试者。我们没有发现2型糖尿病患者小脂肪细胞耗竭的证据。这表明2型糖尿病患者存在脂肪细胞早期成熟缺陷。
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