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本文引用的文献

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Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in diabetic and healthy subjects.糖尿病患者与健康受试者体内金属蛋白酶2和9水平及其抑制剂的评估
Diabetes Metab. 2007 Apr;33(2):129-34. doi: 10.1016/j.diabet.2006.11.008. Epub 2007 Feb 22.
2
Decreased expression of adipogenic genes in obese subjects with type 2 diabetes.2型糖尿病肥胖受试者中脂肪生成基因表达降低。
Obesity (Silver Spring). 2006 Sep;14(9):1543-52. doi: 10.1038/oby.2006.178.
3
Measuring committed preadipocytes in human adipose tissue from severely obese patients by using adipocyte fatty acid binding protein.利用脂肪细胞脂肪酸结合蛋白测定重度肥胖患者人体脂肪组织中已定向的前脂肪细胞。
Am J Physiol Regul Integr Comp Physiol. 2004 Nov;287(5):R1132-40. doi: 10.1152/ajpregu.00337.2004. Epub 2004 Jul 29.
4
Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans.肥胖人群腹部内脏和皮下脂肪组织中的脂肪组织、脂肪组织基质及脂肪细胞释放脂肪因子的比较。
Endocrinology. 2004 May;145(5):2273-82. doi: 10.1210/en.2003-1336. Epub 2004 Jan 15.
5
Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome.组织特异性糖皮质激素激活酶，11β-羟基类固醇脱氢酶1型（11β-HSD1）——治疗代谢综合征的一个有前景的药物靶点。
Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):255-62. doi: 10.2174/1568008033340135.
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Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes.“展望未来”（糖尿病健康行动）：一项旨在预防2型糖尿病患者心血管疾病的减肥临床试验的设计与方法
Control Clin Trials. 2003 Oct;24(5):610-28. doi: 10.1016/s0197-2456(03)00064-3.
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Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women.体重指数和年龄对女性脂肪组织细胞构成及分化能力的影响。
Int J Obes Relat Metab Disord. 2003 Aug;27(8):889-95. doi: 10.1038/sj.ijo.0802314.
8
Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation.基质金属蛋白酶在肥胖期间的脂肪组织中差异表达，并调节脂肪细胞分化。
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9
Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity.肥胖对小鼠基质金属蛋白酶及其组织抑制剂在脂肪组织中表达的调节作用。
Diabetes. 2002 Apr;51(4):1093-101. doi: 10.2337/diabetes.51.4.1093.
10
Stromelysin-1 regulates adipogenesis during mammary gland involution.基质溶解素-1在乳腺退化过程中调节脂肪生成。
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基质金属蛋白酶-2（MMP2）转录增加在2型糖尿病脂肪生成受损中的潜在作用。

Potential role of increased matrix metalloproteinase-2 (MMP2) transcription in impaired adipogenesis in type 2 diabetes mellitus.

作者信息

Dubois Severine G, Tchoukalova Yourka D, Heilbronn Leonie K, Albu Jeanine B, Kelley David E, Smith Steven R, Fang Xiaobing, Ravussin Eric

机构信息

Health & Performance Enhancement Division, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.

出版信息

Biochem Biophys Res Commun. 2008 Mar 21;367(4):725-8. doi: 10.1016/j.bbrc.2007.12.180. Epub 2008 Jan 7.

DOI:10.1016/j.bbrc.2007.12.180
PMID:18182154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2747303/
Abstract

We measured gene expression of paracrine regulators involved in adipocyte differentiation within the stromovascular fraction of abdominal subcutaneous adipose tissue from obese individuals with (n=30) and without (n=18) type 2 diabetes mellitus (T2DM). Despite similar adiposity by design, subjects with T2DM had larger adipocytes (0.92+/-0.28 vs. 0.75+/-0.17 microl, p<0.05) than controls. Gene expression of the adipogenic marker aP2 was lower (0.35+/-0.16 vs. 0.58+/-0.27 arbitrary units, p<0.05) whereas the expression of matricellular peptidase, MMP2 was higher (1.65+/-0.17 vs. 1.27+/-0.21, p=0.02) in T2DM vs. controls. The gene expression levels between the aP2 and MMP2 were inversely correlated (r=-0.32, p=0.03). We conclude that early steps of adipogenesis may be impaired in T2DM independently of obesity due, in part, to an upregulation of the MMP2 transcription.

摘要

我们测定了患有2型糖尿病（T2DM）（n = 30）和未患2型糖尿病（n = 18）的肥胖个体腹部皮下脂肪组织血管基质部分中参与脂肪细胞分化的旁分泌调节因子的基因表达。尽管设计上肥胖程度相似，但患有T2DM的受试者的脂肪细胞比对照组更大（0.92±0.28对0.75±0.17微升，p<0.05）。与对照组相比，T2DM患者中脂肪生成标志物aP2的基因表达较低（0.35±0.16对0.58±0.27任意单位，p<0.05），而基质细胞蛋白酶MMP2的表达较高（1.65±0.17对1.27±0.21，p = 0.02）。aP2和MMP2之间的基因表达水平呈负相关（r = -0.32，p = 0.03）。我们得出结论，T2DM患者脂肪生成的早期步骤可能独立于肥胖而受损，部分原因是MMP2转录上调。