Kastner Monika, Wilczynski Nancy L, McKibbon Ann K, Garg Amit X, Haynes R Brian
Department of Clinical Epidemiology and Biostatistics, Health Information Research Unit, McMaster University, Hamilton, Ontario, Canada.
J Clin Epidemiol. 2009 Sep;62(9):974-81. doi: 10.1016/j.jclinepi.2008.11.006. Epub 2009 Feb 20.
Systematic reviews of health care topics are valuable summaries of all pertinent studies on focused questions. However, finding all relevant primary studies for systematic reviews remains challenging.
To determine the performance of the Clinical Queries sensitive search filter for diagnostic accuracy studies for retrieving studies for systematic reviews.
We compared the yield of the sensitive Clinical Queries diagnosis search filter for MEDLINE and EMBASE to retrieve studies in diagnostic accuracy systematic reviews reported in ACP Journal Club in 2006.
Twelve of 22 diagnostic accuracy reviews (452 included studies) met the inclusion criteria. After excluding 11 studies not in MEDLINE or EMBASE, 95% of articles (417 of 441) were captured by the sensitive Clinical Queries diagnosis search filter (MEDLINE and EMBASE combined). Of 24 studies not retrieved by the filter, 22 were not diagnostic accuracy studies. Reanalysis of the Clinical Queries filter without these 22 nondiagnosis articles increased its performance to 99% (417 of 419). We found no substantive impact of the two articles missed by the Clinical Queries filter on the conclusions of the systematic reviews in which they were cited.
The sensitive Clinical Queries diagnostic search filter captured 99% of articles and 100% of substantive articles indexed in MEDLINE and EMBASE in diagnostic accuracy systematic reviews.
对医疗保健主题进行系统评价是对聚焦问题的所有相关研究的有价值总结。然而，为系统评价找到所有相关的原始研究仍然具有挑战性。
确定临床问题敏感搜索过滤器在检索用于系统评价的诊断准确性研究方面的性能。
我们比较了MEDLINE和EMBASE的敏感临床问题诊断搜索过滤器在检索2006年《美国内科医师学会杂志俱乐部》报道的诊断准确性系统评价中的研究时的产出。
22项诊断准确性评价中的12项（包括452项研究）符合纳入标准。在排除11项不在MEDLINE或EMBASE中的研究后，95%的文章（441篇中的417篇）被敏感临床问题诊断搜索过滤器（MEDLINE和EMBASE合并）捕获。在过滤器未检索到的24项研究中，22项不是诊断准确性研究。对不包括这22篇非诊断性文章的临床问题过滤器进行重新分析，其性能提高到99%（419篇中的417篇）。我们发现临床问题过滤器遗漏的两篇文章对它们被引用的系统评价的结论没有实质性影响。
在诊断准确性系统评价中，敏感临床问题诊断搜索过滤器捕获了MEDLINE和EMBASE中索引的99%的文章和100%的实质性文章。
