Van Dooren A A
Pharm Weekbl Sci. 1991 Jun 21;13(3):109-18. doi: 10.1007/BF01981526.
In this report the state of the art with respect to PVC as pharmaceutical packaging material is described. A general introduction into the applications of PVC is followed by a description of its production process. The metabolic effects of the monomer of PVC, vinyl chloride and of the most commonly used plasticizer diethylhexylphthalate are mentioned. Special attention is given to the pharmaceutical properties of plasticized PVC bags in comparison to other plastics and the environmental aspects of waste PVC disposal. Although there are emotional and political queries regarding the future use of PVC as a (pharmaceutical) packaging material, we conclude that there is no scientific justification for a total or partial ban of PVC. PVC will remain a fact of life as a cheap, versatile, high-performance and well-investigated plastic material for medical and pharmaceutical applications, to be replaced by newer plastics only for certain well-defined indications where the requirements of the plastic to be used are so specific that it will economically and technically be justified to use another polymer. Community and hospital pharmacists have to be prepared for a role in intake of waste plastic disposables, probably against deposit money, in order to fulfil the logistics needed for recycling.
本报告描述了聚氯乙烯（PVC）作为药品包装材料的技术现状。在对PVC的应用进行总体介绍之后，描述了其生产过程。提及了PVC单体氯乙烯以及最常用的增塑剂邻苯二甲酸二乙酯的代谢影响。与其他塑料相比，特别关注了增塑PVC袋的药学性质以及废弃PVC处置的环境问题。尽管对于PVC作为（药品）包装材料的未来使用存在情绪化和政治性的质疑，但我们得出结论，全面或部分禁止PVC没有科学依据。PVC将作为一种廉价、通用、高性能且经过充分研究的塑料材料，继续存在于医疗和制药应用中，只有在某些明确界定的特定情况下，即所使用塑料的要求非常特殊，以至于从经济和技术角度使用另一种聚合物才合理时，才会被新型塑料所取代。社区和医院药剂师必须准备好承担回收废弃一次性塑料制品的工作，可能需要收取押金，以完成回收所需的物流工作。
