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Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006.加拿大重症监护病房中的耐抗菌性病原体：2005 - 2006年加拿大国家重症监护病房（CAN - ICU）研究结果
Antimicrob Agents Chemother. 2008 Apr;52(4):1430-7. doi: 10.1128/AAC.01538-07. Epub 2008 Feb 19.
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Synthetic lipopeptides: a novel class of anti-infectives.合成脂肽：一类新型抗感染药物。
Expert Opin Investig Drugs. 2007 Aug;16(8):1159-69. doi: 10.1517/13543784.16.8.1159.
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The acyl group as the central element of the structural organization of antimicrobial lipopeptide.酰基作为抗微生物脂肽结构组织的核心元素。
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The world of beta- and gamma-peptides comprised of homologated proteinogenic amino acids and other components.由同源蛋白质氨基酸和其他成分组成的β-肽和γ-肽世界。
Chem Biodivers. 2004 Aug;1(8):1111-239. doi: 10.1002/cbdv.200490087.
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Curr Protein Pept Sci. 2006 Dec;7(6):479-86. doi: 10.2174/138920306779025620.
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Ultrashort antibacterial and antifungal lipopeptides.超短抗菌和抗真菌脂肽。
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15997-6002. doi: 10.1073/pnas.0606129103. Epub 2006 Oct 12.
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Biochem J. 2005 Jan 1;385(Pt 1):135-43. doi: 10.1042/BJ20041270.
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Effect of drastic sequence alteration and D-amino acid incorporation on the membrane binding behavior of lytic peptides.剧烈的序列改变和D-氨基酸掺入对裂解肽膜结合行为的影响。
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A new group of antifungal and antibacterial lipopeptides derived from non-membrane active peptides conjugated to palmitic acid.一组新的抗真菌和抗菌脂肽，由与棕榈酸缀合的非膜活性肽衍生而来。
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超短阳离子脂肽的抗菌活性

Antibacterial activity of ultrashort cationic lipo-beta-peptides.

作者信息

Serrano Griselda N, Zhanel George G, Schweizer Frank

机构信息

Department of Chemistry, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.

出版信息

Antimicrob Agents Chemother. 2009 May;53(5):2215-7. doi: 10.1128/AAC.01100-08. Epub 2009 Feb 23.

DOI:10.1128/AAC.01100-08
PMID:19237652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2681537/
Abstract

Previously reported D,L-lipo-alpha-peptides and their lipo-beta-peptide counterparts (C16-KGGK, C16-KAAK, C16-KKKK, and C12-KLLK) were studied, and the lipo-beta-peptides were found to retain antimicrobial activity. Likewise, no significant changes in antimicrobial activity were found upon activity comparisons with D,L-amino acid-based lipopeptides or any L-amino acid lipopeptides. As a defined amphipathic structure is unlikely to form with such short molecules and as similar activities were obtained from all lipopeptides, we suspect that the action of membrane permeation is retained.

摘要

对先前报道的D，L-脂-α-肽及其脂-β-肽类似物（C16-KGGK、C16-KAAK、C16-KKKK和C12-KLLK）进行了研究，发现脂-β-肽保留了抗菌活性。同样，与基于D，L-氨基酸的脂肽或任何L-氨基酸脂肽进行活性比较时，未发现抗菌活性有显著变化。由于如此短的分子不太可能形成明确的两亲结构，并且所有脂肽都具有相似的活性，我们怀疑膜渗透作用得以保留。