超短阳离子脂肽的抗菌活性
Antibacterial activity of ultrashort cationic lipo-beta-peptides.
作者信息
Serrano Griselda N, Zhanel George G, Schweizer Frank
机构信息
Department of Chemistry, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
出版信息
Antimicrob Agents Chemother. 2009 May;53(5):2215-7. doi: 10.1128/AAC.01100-08. Epub 2009 Feb 23.
Abstract
Previously reported D,L-lipo-alpha-peptides and their lipo-beta-peptide counterparts (C16-KGGK, C16-KAAK, C16-KKKK, and C12-KLLK) were studied, and the lipo-beta-peptides were found to retain antimicrobial activity. Likewise, no significant changes in antimicrobial activity were found upon activity comparisons with D,L-amino acid-based lipopeptides or any L-amino acid lipopeptides. As a defined amphipathic structure is unlikely to form with such short molecules and as similar activities were obtained from all lipopeptides, we suspect that the action of membrane permeation is retained.
摘要
对先前报道的D，L-脂-α-肽及其脂-β-肽类似物（C16-KGGK、C16-KAAK、C16-KKKK和C12-KLLK）进行了研究，发现脂-β-肽保留了抗菌活性。同样，与基于D，L-氨基酸的脂肽或任何L-氨基酸脂肽进行活性比较时，未发现抗菌活性有显著变化。由于如此短的分子不太可能形成明确的两亲结构，并且所有脂肽都具有相似的活性，我们怀疑膜渗透作用得以保留。
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