Zentella A, Manogue K, Cerami A
Programm of Cell Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021.
Prog Clin Biol Res. 1991;367:9-24.
A traditional view has been that bacterial products, such as endotoxins from gram negative bacteria, have a direct deleterious effect on the host, resulting in fever, hypermetabolism, anorexia, and tissue damage. In recent years, however, it has been shown that endogenous products of the host, secreted by macrophages and other cellular elements of the immune system, act as mediators in activating the metabolic and other physiological changes characteristic of the sepsis syndrome. We will review in depth various aspects of the major, central mediator, i.e., tissue necrosis factor (TNF)/cachectin, and also briefly discuss the interleukins IL-6 and IL-1.
传统观点认为，细菌产物，如革兰氏阴性菌的内毒素，会对宿主产生直接有害影响，导致发热、代谢亢进、厌食和组织损伤。然而，近年来研究表明，宿主的内源性产物，由巨噬细胞和免疫系统的其他细胞成分分泌，在激活脓毒症综合征特有的代谢和其他生理变化中起介质作用。我们将深入综述主要的核心介质——组织坏死因子（TNF）/消瘦素的各个方面，还将简要讨论白细胞介素IL - 6和IL - 1。
