单结构域应答调节因子：在细胞组织和动态变化中发挥新作用的分子开关
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
作者信息
Jenal Urs, Galperin Michael Y
机构信息
Biozentrum, University of Basel, Switzerland.
出版信息
Curr Opin Microbiol. 2009 Apr;12(2):152-60. doi: 10.1016/j.mib.2009.01.010. Epub 2009 Feb 24.
Abstract
Single domain response regulators (SD-RRs) are signaling components of two-component phosphorylation pathways that harbor a phosphoryl receiver domain but lack a dedicated output domain. The Escherichia coli protein CheY, the paradigm member of this family, regulates chemotaxis by relaying information between chemoreceptors and the flagellar motor switch. New data provide a more complex picture of CheY-mediated motility control in several bacteria and suggest diverging mechanisms in control of cellular motors. Moreover, advances have been made in understanding cellular functions of SD-RRs beyond chemotaxis. We review recent reports indicating that SD-RRs constitute a family of versatile molecular switches that contribute to cellular organization and dynamics as spatial organizer and/or as allosteric regulators of histidine protein kinases.
摘要
单结构域应答调节蛋白（SD-RRs）是双组分磷酸化信号通路的信号传导元件，其含有一个磷酸化受体结构域，但缺少一个专门的输出结构域。该家族的典型成员——大肠杆菌蛋白CheY，通过在化学感受器和鞭毛马达开关之间传递信息来调节趋化性。新数据为几种细菌中CheY介导的运动控制提供了更复杂的情况，并表明在细胞马达控制方面存在不同的机制。此外，在理解SD-RRs除趋化性之外的细胞功能方面也取得了进展。我们综述了最近的报告，这些报告表明SD-RRs构成了一类多功能分子开关，作为空间组织者和/或组氨酸蛋白激酶的变构调节剂，对细胞组织和动态变化有贡献。
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