膳食纤维与胃癌风险：一项来自意大利的病例对照研究。

Dietary fiber and stomach cancer risk: a case-control study from Italy.

作者信息

Bravi Francesca, Scotti Lorenza, Bosetti Cristina, Bertuccio Paola, Negri Eva, La Vecchia Carlo

机构信息

Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, Milan, MI 20156, Italy.

出版信息

Cancer Causes Control. 2009 Aug;20(6):847-53. doi: 10.1007/s10552-009-9309-z. Epub 2009 Feb 27.

DOI:10.1007/s10552-009-9309-z

PMID:19247788

Abstract

OBJECTIVE

Fiber intake has been inversely related to stomach cancer risk, although this issue is still controversial.

METHODS

A case-control study was conducted in Italy between 1997 and 2007, including 230 cases with incident, histologically confirmed stomach cancer, and 547 controls with acute, non-neoplastic diseases. Dietary habits were investigated through a validated food frequency questionnaire.

RESULTS

Compared with the lowest quintile of intake, the multivariate odds ratios (ORs, including terms for major recognised confounding factors and total energy intake) for the highest quintile were 0.47 (95% confidence interval (CI): 0.28-0.79) for total fiber, 0.50 (95% CI: 0.30-0.85) for soluble non-cellulose polysaccharides (NCP), 0.39 (95% CI: 0.23-0.66) for total insoluble fiber, 0.54 (95% CI: 0.32-0.91) for insoluble NCP, 0.37 (95% CI: 0.22-0.64) for cellulose, and 0.59 (95% CI: 0.36-0.98) for lignin. With reference to the sources of fiber, an inverse association was found for fiber from vegetable (OR = 0.42, 95% CI: 0.24-0.72), and to a lesser extent from fruit (OR = 0.65, 95% CI: 0.38-1.10), but not for fiber from grain (OR = 1.25, 95% CI: 0.77-2.03).

CONCLUSIONS

This study found an inverse relationship between stomach cancer risk and various types of fiber, derived, in particular, from vegetables and fruit.

摘要

目的

膳食纤维摄入量与胃癌风险呈负相关，尽管这一问题仍存在争议。

方法

1997年至2007年在意大利进行了一项病例对照研究，包括230例新发病例、经组织学确诊的胃癌患者，以及547例患有急性非肿瘤性疾病的对照者。通过一份经过验证的食物频率问卷对饮食习惯进行调查。

结果

与摄入量最低的五分位数相比，最高五分位数的多因素优势比（OR，包括主要公认混杂因素和总能量摄入的项），总膳食纤维为0.47（95%置信区间（CI）：0.28 - 0.79），可溶性非纤维素多糖（NCP）为0.50（95% CI：0.30 - 0.85），总不溶性膳食纤维为0.39（95% CI：0.23 - 0.66），不溶性NCP为0.54（95% CI：0.32 - 0.91），纤维素为0.37（95% CI：0.22 - 0.64），木质素为0.59（95% CI：0.36 - 0.98）。关于膳食纤维的来源，发现蔬菜来源的膳食纤维呈负相关（OR = 0.42，95% CI：0.24 - 0.72），水果来源的膳食纤维在较小程度上呈负相关（OR = 0.65，95% CI：0.38 - 1.10），但谷物来源的膳食纤维无负相关（OR = 1.25，95% CI：0.77 - 2.03）。