State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Cancer Sci. 2013 Aug;104(8):1067-73. doi: 10.1111/cas.12195. Epub 2013 Jun 21.
The relationship between consumption of cruciferous vegetables (CV) and risk of gastric cancer has been investigated by many studies, but remains controversial. We carried out a meta-analysis to summarize available evidence from epidemiological studies on this point. Relevant published reports of CV intake and gastric cancer were identified using MEDLINE (PubMed), EMBASE, and Web of Science databases through to the end of September 2012. We pooled the relative risk from individual studies using a fixed- or random-effects model and carried out heterogeneity and publication bias analyses. Sixteen case-control and six prospective studies were included in our analysis. When all studies were pooled, we yielded a significantly inverse association between CV (relative risk = 0.81; 95% confidence interval, 0.75-0.88) intake and gastric cancer risk, with little heterogeneity (Q = 27.27, P = 0.292, I(2) = 12.0%). Specific analysis for cabbage intake yielded similar result. When separately analyzed, case-control studies of CV intake yielded significant results and the results of prospective studies showed borderline statistical significance. Moreover, significant results were consistent for high-quality studies, for North American, European, and Asian studies, for studies on males, and for studies on non-cardia gastric cancer. Findings from this meta-analysis provide evidence that high intake of CV was inversely associated with the risk of gastric cancer and non-cardia gastric cancer in humans. Further studies on other specific CV, food preparation methods, and stratified results by anatomic cancer site and histological type should be extended in the future.
十字花科蔬菜（CV）的消费与胃癌风险之间的关系已经被许多研究调查过，但仍然存在争议。我们进行了一项荟萃分析，以总结关于这一点的流行病学研究的现有证据。通过 MEDLINE（PubMed）、EMBASE 和 Web of Science 数据库，检索截至 2012 年 9 月底发表的关于 CV 摄入和胃癌的相关报告。我们使用固定或随机效应模型对来自个体研究的相对风险进行汇总，并进行异质性和发表偏倚分析。我们的分析包括 16 项病例对照研究和 6 项前瞻性研究。当汇总所有研究时，我们发现 CV（相对风险=0.81；95%置信区间，0.75-0.88）摄入与胃癌风险之间存在显著的负相关关系，异质性较小（Q=27.27，P=0.292，I(2)=12.0%）。对卷心菜摄入的具体分析得出了类似的结果。对 CV 摄入的病例对照研究的单独分析得出了显著的结果，前瞻性研究的结果则显示出边缘统计学意义。此外，高质量研究、北美、欧洲和亚洲的研究、男性研究和非贲门胃癌研究的结果均一致。这项荟萃分析的结果提供了证据表明，大量摄入 CV 与人类胃癌和非贲门胃癌的风险呈负相关。未来应该进一步开展对其他特定的 CV、食物制备方法以及按解剖癌位和组织学类型分层的结果的研究。
