Wu Xiao-Ning, Zhao Xin-Yan, Jia Ji-Dong
Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Xuanwu District, Beijing, China.
World J Gastroenterol. 2009 Feb 28;15(8):1014-7. doi: 10.3748/wjg.15.1014.
We report a case of a 62-year old woman admitted to our hospital for multiple nodular metastatic liver lesions found by ultrasonography in a regular medical examination. Routine laboratory tests were normal. PET-CT showed multiple bone lesions and nodular liver lesions. Liver biopsy revealed nodular infiltration of multiple myeloma with positive staining of kappa light chain. Further investigation of bone marrow aspiration, immunofixation and immunoelectrophoresis of serum protein, urine test for Bence-Jones protein, beta(2)-microglobulin in serum and urine confirmed the diagnosis. The patient also coinfected with hepatitis C virus (HCV). With six cycles of chemotherapy with VAD schedule, she achieved complete remission. In this report, a literature review of liver lesions involving multiple myeloma is also provided.
我们报告一例62岁女性，因在常规体检中经超声检查发现肝脏有多个结节性转移病灶而入住我院。常规实验室检查结果正常。PET-CT显示多处骨病变和肝脏结节性病变。肝脏活检显示多发性骨髓瘤结节性浸润，kappa轻链染色阳性。进一步进行骨髓穿刺检查、血清蛋白免疫固定和免疫电泳、尿本周蛋白检测、血清和尿液中的β2微球蛋白检测，确诊了病情。该患者还合并丙型肝炎病毒（HCV）感染。采用VAD方案进行六个周期的化疗后，她实现了完全缓解。本报告还提供了关于多发性骨髓瘤累及肝脏病变的文献综述。
