Wadehra Anshu, Chokshi Bhavin, Buechler Connor R, Singh Manmeet M
Internal Medicine, Wayne State University/Detroit Medical Center, Detroit, USA.
Cureus. 2020 Dec 28;12(12):e12346. doi: 10.7759/cureus.12346.
Multiple myeloma affects upwards of 30,000 people every year and has significant morbidity and mortality. Common complications of the disease involve lytic bone lesions, hypercalcemia, anemia, and acute renal failure. A rare, yet serious, complication includes acute liver failure secondary to hepatic plasma cell infiltration. While this is reported seldom in living patients, it is found in upwards of 40% of patients incidentally on imaging or during autopsy. Conscientious and meticulous monitoring of liver function tests allows for early detection of liver failure in multiple myeloma; thus, allowing for broader therapeutic options overall.
每年有超过3万人受到多发性骨髓瘤的影响，该病具有较高的发病率和死亡率。该疾病的常见并发症包括溶骨性骨病变、高钙血症、贫血和急性肾衰竭。一种罕见但严重的并发症是继发于肝浆细胞浸润的急性肝衰竭。虽然这种情况在在世患者中很少报道，但在超过40%的患者中，在影像学检查或尸检时偶然发现。认真细致地监测肝功能检查有助于早期发现多发性骨髓瘤患者的肝衰竭；因此，总体上可提供更广泛的治疗选择。
